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Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats

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dc.contributor.authorMarkkula, S Pauliina
dc.contributor.authorLyons, David
dc.contributor.authorYueh, Chen-Yu
dc.contributor.authorRiches, Christine
dc.contributor.authorHurst, Paul
dc.contributor.authorFielding, Barbara
dc.contributor.authorHeisler, Lora K
dc.contributor.authorEvans, Mark L
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2016-12-05T14:28:18Z
dc.date.available2016-12-05T14:28:18Z
dc.date.issued2016-10-14
dc.descriptionStudies were funded by the Juvenile Diabetes Research Foundation (1–2006 –29) and Diabetes UK (RD05/003059) toMLE, the Wellcome Trust (WT098012) to LKH and Cambridge MRC Centre for Study of Obesity and Related Disorders (MRCCORD). In addition, PhD studentships/ fellowships were supported for SPM (Elmore Fund), PH (Sir Jules Thorn Trust) and C-YY Chang Gung University College of Medicine). We are grateful to Keith Burling and colleagues in the Cambridge MRCCORD and Department of Clinical Biochemistry, Cambridge University Hospitals NHS foundation trust (Addenbrookes Hospital), Cambridge for performing hormonal assays, to Dr Nicola Jackson (University of Surrey) for help with establishing the GC-MS method for plasma glucose stable isotope measure ments, to Mrs Jill Shaw for technical assistance with rodent studies and to Prof Malcolm Low (University of Michigan) for the generous gift of POMCDS-Red miceen
dc.description.statusPeer revieweden
dc.format.extent8
dc.format.extent1231467
dc.identifier72368312
dc.identifier37b84124-fb2c-4424-bd85-1ac3a1bb1b7f
dc.identifier27740870
dc.identifier85002292144
dc.identifier.citationMarkkula, S P, Lyons, D, Yueh, C-Y, Riches, C, Hurst, P, Fielding, B, Heisler, L K & Evans, M L 2016, 'Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats', Endocrinology, vol. 157, no. 12, pp. 4669–4676. https://doi.org/10.1210/en.2015-2054en
dc.identifier.doi10.1210/en.2015-2054
dc.identifier.iss12en
dc.identifier.issn0013-7227
dc.identifier.otherORCID: /0000-0002-7731-1419/work/30894578
dc.identifier.urihttp://hdl.handle.net/2164/7822
dc.identifier.vol157en
dc.language.isoeng
dc.relation.ispartofEndocrinologyen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subjectWT098012en
dc.subject.lccRen
dc.titleIntracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Ratsen
dc.typeJournal articleen

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