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In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional study

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dc.contributor.authorHyötyläinen, Tuulia
dc.contributor.authorMcGlinchey, Aidan
dc.contributor.authorSalihovic, Samira
dc.contributor.authorSchubert, Antonia
dc.contributor.authorDouglas, Alex
dc.contributor.authorHay, David C
dc.contributor.authorO'Shaughnessy, Peter J
dc.contributor.authorIredale, John P
dc.contributor.authorShaw, Sophie
dc.contributor.authorFowler, Paul A
dc.contributor.authorOrešič, Matej
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2024-01-09T14:16:01Z
dc.date.available2024-01-09T14:16:01Z
dc.date.issued2024-01
dc.descriptionThe Fetal Human study was funded by the UK Medical Research Council (MR/L010011/1) to PAF, PJO’S, JPI, DCH, and AD, by the Seventh Framework Programme of the European Union under Grant Agreement 212885, and by NHS Grampian Endowments grants (08/02, 09/12, 13/56, and 15/1/010) to PAF. The metabolomics and exposomics study was supported by the Swedish Research Council (to TH and MO; grants 2016-05176 and 2020-03674), Formas (to TH and MO; grant 2019-00869), Novo Nordisk Foundation (to TH; grant NNF20OC0063971), Research Council of Finland (to MO; grant 333981), the Inflammation in human early life: targeting impacts on life-course health consortium funded by the Horizon Europe Program of the European Union (Grant Agreement 101094099 to MO, TH, and PAF), and the framework of the European Partnership for the Assessment of Risks from Chemicals, and has received funding from the European Union's Horizon Europe research and innovation programme (grant agreement 101057014). Views and opinions expressed are, however, those of the author(s) only and do not necessarily reflect those of the European Union or the Health and Digital Executive Agency. Neither the European Union nor the granting authority can be held responsible for them. The authors would like to thank (1) the Fowler team members, NHS Grampian research nurses, and staff at the Pregnancy Counselling Service for their essential work in recruiting, collecting, and processing fetuses; and (2) the Centre for Genome Enabled Biology and Medicine, University of Aberdeen, for carrying out the RNA-Seq. The RNA-Seq data analysis was supported by use of the University of Aberdeen Maxwell High Performance Computer Cluster.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent6177895
dc.identifier283479038
dc.identifiera90197cd-aa0d-4bc7-964e-8758cd9a3099
dc.identifier38199723
dc.identifier85181938990
dc.identifier.citationHyötyläinen, T, McGlinchey, A, Salihovic, S, Schubert, A, Douglas, A, Hay, D C, O'Shaughnessy, P J, Iredale, J P, Shaw, S, Fowler, P A & Orešič, M 2024, 'In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional study', The Lancet Planetary Health, vol. 8, no. 1, pp. e5-e17. https://doi.org/10.1016/S2542-5196(23)00257-7en
dc.identifier.doi10.1016/S2542-5196(23)00257-7
dc.identifier.iss1en
dc.identifier.issn2542-5196
dc.identifier.otherRIS: urn:8DE822DA696DBD30B7F28E802437FA1F
dc.identifier.otherORCID: /0000-0001-6606-1058/work/150761646
dc.identifier.otherORCID: /0000-0002-4831-9075/work/150762033
dc.identifier.urihttps://hdl.handle.net/2164/22516
dc.identifier.vol8en
dc.language.isoeng
dc.relation.ispartofThe Lancet Planetary Healthen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectGE Environmental Sciencesen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L010011/1en
dc.subjectEuropean Research Councilen
dc.subject212885en
dc.subject101094099en
dc.subject.lccGEen
dc.titleIn utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland : a cross-sectional studyen
dc.typeJournal articleen

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