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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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dc.contributor.authorKilpeläinen, Tuomas O.
dc.contributor.authorBentley, Amy R.
dc.contributor.authorNoordam, Raymond
dc.contributor.authorSung, Yun Ju
dc.contributor.authorSchwander, Karen
dc.contributor.authorWinkler, Thomas W.
dc.contributor.authorJakupović, Hermina
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorManning, Alisa
dc.contributor.authorNtalla, Ioanna
dc.contributor.authorAschard, Hugues
dc.contributor.authorBrown, Michael R.
dc.contributor.authorde las Fuentes, Lisa
dc.contributor.authorFranceschini, Nora
dc.contributor.authorGuo, Xiuqing
dc.contributor.authorVojinovic, Dina
dc.contributor.authorAslibekyan, Stella
dc.contributor.authorFeitosa, Mary F.
dc.contributor.authorKho, Minjung
dc.contributor.authorMusani, Solomon K.
dc.contributor.authorRichard, Melissa
dc.contributor.authorWang, Heming
dc.contributor.authorWang, Zhe
dc.contributor.authorBartz, Traci M.
dc.contributor.authorBielak, Lawrence F.
dc.contributor.authorCampbell, Archie
dc.contributor.authorDorajoo, Rajkumar
dc.contributor.authorFisher, Virginia
dc.contributor.authorHartwig, Fernando P.
dc.contributor.authorHorimoto, Andrea R. V. R.
dc.contributor.authorLi, Changwei
dc.contributor.authorLohman, Kurt K.
dc.contributor.authorMarten, Jonathan
dc.contributor.authorSim, Xueling
dc.contributor.authorSmith, Albert V.
dc.contributor.authorTajuddin, Salman M.
dc.contributor.authorAlver, Maris
dc.contributor.authorAmini, Marzyeh
dc.contributor.authorBoissel, Mathilde
dc.contributor.authorChai, Jin Fang
dc.contributor.authorChen, Xu
dc.contributor.authorDivers, Jasmin
dc.contributor.authorEvangelou, Evangelos
dc.contributor.authorGao, Chuan
dc.contributor.authorGraff, Mariaelisa
dc.contributor.authorHarris, Sarah E.
dc.contributor.authorHe, Meian
dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorJackson, Anne U.
dc.contributor.authorZhao, Jing Hua
dc.contributor.authorKraja, Aldi T.
dc.contributor.authorKühnel, Brigitte
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorNolte, Ilja M.
dc.contributor.authorRauramaa, Rainer
dc.contributor.authorRiaz, Muhammad
dc.contributor.authorRobino, Antonietta
dc.contributor.authorRueedi, Rico
dc.contributor.authorStringham, Heather M.
dc.contributor.authorTakeuchi, Fumihiko
dc.contributor.authorvan der Most, Peter J.
dc.contributor.authorVarga, Tibor V.
dc.contributor.authorVerweij, Niek
dc.contributor.authorWare, Erin B.
dc.contributor.authorWen, Wanqing
dc.contributor.authorLi, Xiaoyin
dc.contributor.authorYanek, Lisa R.
dc.contributor.authorAmin, Najaf
dc.contributor.authorArnett, Donna K.
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBrumat, Marco
dc.contributor.authorCade, Brian
dc.contributor.authorCanouil, Mickaël
dc.contributor.authorChen, Yii-Der Ida
dc.contributor.authorConcas, Maria Pina
dc.contributor.authorConnell, John
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorde Silva, H. Janaka
dc.contributor.authorde Vries, Paul S.
dc.contributor.authorDemirkan, Ayşe
dc.contributor.authorDing, Jingzhong
dc.contributor.authorEaton, Charles B.
dc.contributor.authorFaul, Jessica D.
dc.contributor.authorFriedlander, Yechiel
dc.contributor.authorGabriel, Kelley P.
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorGiulianini, Franco
dc.contributor.authorGu, Chi Charles
dc.contributor.authorGu, Dongfeng
dc.contributor.authorHarris, Tamara B.
dc.contributor.authorHe, Jiang
dc.contributor.authorHeikkinen, Sami
dc.contributor.authorHeng, Chew-Kiat
dc.contributor.authorHunt, Steven C.
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorJonas, Jost B.
dc.contributor.authorKoh, Woon-Puay
dc.contributor.authorKomulainen, Pirjo
dc.contributor.authorKrieger, Jose E.
dc.contributor.authorKritchevsky, Stephen B.
dc.contributor.authorKutalik, Zoltán
dc.contributor.authorKuusisto, Johanna
dc.contributor.authorLangefeld, Carl D.
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorLauner, Lenore J.
dc.contributor.authorLeander, Karin
dc.contributor.authorLemaitre, Rozenn N.
dc.contributor.authorLewis, Cora E.
dc.contributor.authorLiang, Jingjing
dc.contributor.authorAlizadeh, Behrooz Z.
dc.contributor.authorBoezen, H. Marike
dc.contributor.authorFranke, Lude
dc.contributor.authorNavis, Gerjan
dc.contributor.authorRots, Marianne
dc.contributor.authorSwertz, Morris
dc.contributor.authorWolffenbuttel, Bruce H. R.
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorLiu, Jianjun
dc.contributor.authorMägi, Reedik
dc.contributor.authorManichaikul, Ani
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMohlke, Karen L.
dc.contributor.authorMosley, Thomas H.
dc.contributor.authorMurray, Alison D.
dc.contributor.authorNalls, Mike A.
dc.contributor.authorNang, Ei-Ei Khaing
dc.contributor.authorNelson, Christopher P.
dc.contributor.authorNona, Sotoodehnia
dc.contributor.authorNorris, Jill M.
dc.contributor.authorNwuba, Chiamaka Vivian
dc.contributor.authorO’Connell, Jeff
dc.contributor.authorPalmer, Nicholette D.
dc.contributor.authorPapanicolau, George J.
dc.contributor.authorPazoki, Raha
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPeters, Annette
dc.contributor.authorPeyser, Patricia A.
dc.contributor.authorPolasek, Ozren
dc.contributor.authorPorteous, David J.
dc.contributor.authorPoveda, Alaitz
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorRich, Stephen S.
dc.contributor.authorRisch, Neil
dc.contributor.authorRobinson, Jennifer G.
dc.contributor.authorRose, Lynda M.
dc.contributor.authorRudan, Igor
dc.contributor.authorSchreiner, Pamela J.
dc.contributor.authorScott, Robert A.
dc.contributor.authorSidney, Stephen S.
dc.contributor.authorSims, Mario
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorSnieder, Harold
dc.contributor.authorSofer, Tamar
dc.contributor.authorStarr, John M.
dc.contributor.authorSternfeld, Barbara
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorTang, Hua
dc.contributor.authorTaylor, Kent D.
dc.contributor.authorTsai, Michael Y.
dc.contributor.authorTuomilehto, Jaakko
dc.contributor.authorUitterlinden, André G.
dc.contributor.authorvan der Ende, M. Yldau
dc.contributor.authorvan Heemst, Diana
dc.contributor.authorVoortman, Trudy
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorWennberg, Patrik
dc.contributor.authorWilson, Gregory
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorYao, Jie
dc.contributor.authorYu, Caizheng
dc.contributor.authorYuan, Jian-Min
dc.contributor.authorZhao, Wei
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorBecker, Diane M.
dc.contributor.authorBoehnke, Michael
dc.contributor.authorBowden, Donald W.
dc.contributor.authorde Faire, Ulf
dc.contributor.authorDeary, Ian J.
dc.contributor.authorElliott, Paul
dc.contributor.authorEsko, Tõnu
dc.contributor.authorFreedman, Barry I.
dc.contributor.authorFroguel, Philippe
dc.contributor.authorGasparini, Paolo
dc.contributor.authorGieger, Christian
dc.contributor.authorKato, Norihiro
dc.contributor.authorLaakso, Markku
dc.contributor.authorLakka, Timo A.
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorMagnusson, Patrik K. E.
dc.contributor.authorOldehinkel, Albertine J.
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorSamani, Nilesh J.
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorVan Vliet-Ostaptchouk, Jana V.
dc.contributor.authorVollenweider, Peter
dc.contributor.authorWagenknecht, Lynne E.
dc.contributor.authorWang, Ya X.
dc.contributor.authorWareham, Nicholas J.
dc.contributor.authorWeir, David R.
dc.contributor.authorWu, Tangchun
dc.contributor.authorZheng, Wei
dc.contributor.authorZhu, Xiaofeng
dc.contributor.authorEvans, Michele K.
dc.contributor.authorFranks, Paul W.
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHayward, Caroline
dc.contributor.authorHorta, Bernardo L.
dc.contributor.authorKelly, Tanika N.
dc.contributor.authorLiu, Yongmei
dc.contributor.authorNorth, Kari E.
dc.contributor.authorPereira, Alexandre C.
dc.contributor.authorRidker, Paul M.
dc.contributor.authorTai, E. Shyong
dc.contributor.authorvan Dam, Rob M.
dc.contributor.authorFox, Ervin R.
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorLiu, Ching-Ti
dc.contributor.authorMook-Kanamori, Dennis O.
dc.contributor.authorProvince, Michael A.
dc.contributor.authorRedline, Susan
dc.contributor.authorvan Duijn, Cornelia M.
dc.contributor.authorRotter, Jerome I.
dc.contributor.authorKooperberg, Charles B.
dc.contributor.authorGauderman, W. James
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRice, Kenneth
dc.contributor.authorMunroe, Patricia B.
dc.contributor.authorFornage, Myriam
dc.contributor.authorCupples, L. Adrienne
dc.contributor.authorRotimi, Charles N.
dc.contributor.authorMorrison, Alanna C.
dc.contributor.authorRao, Dabeeru C.
dc.contributor.authorLoos, Ruth J. F.
dc.contributor.authorStudy, Lifelines Cohort
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-01-24T09:40:08Z
dc.date.available2019-01-24T09:40:08Z
dc.date.issued2019-01-22
dc.descriptionThe present work was largely supported by a grant from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (R01HL118305). The full list of acknowledgments appears in the Supplementary Notes 3 and 4.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1792872
dc.identifier141787178
dc.identifier02ff0db8-eb89-4ccb-80c6-2671aea60d70
dc.identifier85060388984
dc.identifier30670697
dc.identifier.citationKilpeläinen, T O, Bentley, A R, Noordam, R, Sung, Y J, Schwander, K, Winkler, T W, Jakupović, H, Chasman, D I, Manning, A, Ntalla, I, Aschard, H, Brown, M R, de las Fuentes, L, Franceschini, N, Guo, X, Vojinovic, D, Aslibekyan, S, Feitosa, M F, Kho, M, Musani, S K, Richard, M, Wang, H, Wang, Z, Bartz, T M, Bielak, L F, Campbell, A, Dorajoo, R, Fisher, V, Hartwig, F P, Horimoto, A R V R, Li, C, Lohman, K K, Marten, J, Sim, X, Smith, A V, Tajuddin, S M, Alver, M, Amini, M, Boissel, M, Chai, J F, Chen, X, Divers, J, Evangelou, E, Gao, C, Graff, M, Harris, S E, He, M, Hsu, F-C, Jackson, A U, Zhao, J H, Kraja, A T, Kühnel, B, Laguzzi, F, Lyytikäinen, L-P, Nolte, I M, Rauramaa, R, Riaz, M, Robino, A, Rueedi, R, Stringham, H M, Takeuchi, F, van der Most, P J, Varga, T V, Verweij, N, Ware, E B, Wen, W, Li, X, Yanek, L R, Amin, N, Arnett, D K, Boerwinkle, E, Brumat, M, Cade, B, Canouil, M, Chen, Y-D I, Concas, M P, Connell, J, de Mutsert, R, de Silva, H J, de Vries, P S, Demirkan, A, Ding, J, Eaton, C B, Faul, J D, Friedlander, Y, Gabriel, K P, Ghanbari, M, Giulianini, F, Gu, C C, Gu, D, Harris, T B, He, J, Heikkinen, S, Heng, C-K, Hunt, S C, Ikram, M A, Jonas, J B, Koh, W-P, Komulainen, P, Krieger, J E, Kritchevsky, S B, Kutalik, Z, Kuusisto, J, Langefeld, C D, Langenberg, C, Launer, L J, Leander, K, Lemaitre, R N, Lewis, C E, Liang, J, Alizadeh, B Z, Boezen, H M, Franke, L, Navis, G, Rots, M, Swertz, M, Wolffenbuttel, B H R, Wijmenga, C, Liu, J, Mägi, R, Manichaikul, A, Meitinger, T, Metspalu, A, Milaneschi, Y, Mohlke, K L, Mosley, T H, Murray, A D, Nalls, M A, Nang, E-E K, Nelson, C P, Nona, S, Norris, J M, Nwuba, C V, O’Connell, J, Palmer, N D, Papanicolau, G J, Pazoki, R, Pedersen, N L, Peters, A, Peyser, P A, Polasek, O, Porteous, D J, Poveda, A, Raitakari, O T, Rich, S S, Risch, N, Robinson, J G, Rose, L M, Rudan, I, Schreiner, P J, Scott, R A, Sidney, S S, Sims, M, Smith, J A, Snieder, H, Sofer, T, Starr, J M, Sternfeld, B, Strauch, K, Tang, H, Taylor, K D, Tsai, M Y, Tuomilehto, J, Uitterlinden, A G, van der Ende, M Y, van Heemst, D, Voortman, T, Waldenberger, M, Wennberg, P, Wilson, G, Xiang, Y-B, Yao, J, Yu, C, Yuan, J-M, Zhao, W, Zonderman, A B, Becker, D M, Boehnke, M, Bowden, D W, de Faire, U, Deary, I J, Elliott, P, Esko, T, Freedman, B I, Froguel, P, Gasparini, P, Gieger, C, Kato, N, Laakso, M, Lakka, T A, Lehtimäki, T, Magnusson, P K E, Oldehinkel, A J, Penninx, B W J H, Samani, N J, Shu, X-O, van der Harst, P, Van Vliet-Ostaptchouk, J V, Vollenweider, P, Wagenknecht, L E, Wang, Y X, Wareham, N J, Weir, D R, Wu, T, Zheng, W, Zhu, X, Evans, M K, Franks, P W, Gudnason, V, Hayward, C, Horta, B L, Kelly, T N, Liu, Y, North, K E, Pereira, A C, Ridker, P M, Tai, E S, van Dam, R M, Fox, E R, Kardia, S L R, Liu, C-T, Mook-Kanamori, D O, Province, M A, Redline, S, van Duijn, C M, Rotter, J I, Kooperberg, C B, Gauderman, W J, Psaty, B M, Rice, K, Munroe, P B, Fornage, M, Cupples, L A, Rotimi, C N, Morrison, A C, Rao, D C, Loos, R J F & Study, L C 2019, 'Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity', Nature Communications, vol. 10, no. 1, 376. https://doi.org/10.1038/s41467-018-08008-wen
dc.identifier.doi10.1038/s41467-018-08008-w
dc.identifier.iss1en
dc.identifier.issn2041-1723
dc.identifier.otherRIS: urn:066700F4141B8F8DD77249F7E6128D00
dc.identifier.otherRIS: Kilpeläinen2019
dc.identifier.otherMendeley: 138c33ca-b490-3d29-859a-a53eea959ab9
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976593
dc.identifier.urihttp://hdl.handle.net/2164/11826
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85060388984&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/multiancestry-study-blood-lipid-levels-identifies-four-loci-interacting-physical-activityen
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofNature Communicationsen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAfrican Continental Ancestry Group/geneticsen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAsian Continental Ancestry Group/geneticsen
dc.subjectBrazilen
dc.subjectCalcium-Binding Proteins/geneticsen
dc.subjectCholesterol, HDL/blooden
dc.subjectCholesterol, LDL/blooden
dc.subjectCholesterol/blooden
dc.subjectEuropean Continental Ancestry Group/geneticsen
dc.subjectExerciseen
dc.subjectFemaleen
dc.subjectGenetic Loci/geneticsen
dc.subjectGenome-Wide Association Studyen
dc.subjectGenotypeen
dc.subjectHispanic Americans/geneticsen
dc.subjectHumansen
dc.subjectLIM-Homeodomain Proteins/geneticsen
dc.subjectLipid Metabolism/geneticsen
dc.subjectLipids/blooden
dc.subjectMaleen
dc.subjectMembrane Proteins/geneticsen
dc.subjectMicrotubule-Associated Proteins/geneticsen
dc.subjectMiddle Ageden
dc.subjectMuscle Proteins/geneticsen
dc.subjectNerve Tissue Proteins/geneticsen
dc.subjectTranscription Factors/geneticsen
dc.subjectTriglycerides/blooden
dc.subjectYoung Adulten
dc.subjectR Medicine (General)en
dc.subjectGeneral Physics and Astronomyen
dc.subjectGeneral Chemistryen
dc.subjectGeneral Biochemistry,Genetics and Molecular Biologyen
dc.subjectSupplementary Dataen
dc.subjectSupplementary data availableen
dc.subject.lccR1en
dc.titleMulti-ancestry study of blood lipid levels identifies four loci interacting with physical activityen
dc.typeJournal articleen

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