University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Simple item page
dc.contributor.authorMcIlroy, George
dc.contributor.authorSuchacki, Karla
dc.contributor.authorRoelofs, Anke J
dc.contributor.authorYang, Wulin
dc.contributor.authorFu, Yanyun
dc.contributor.authorBai, Bo
dc.contributor.authorWallace, Robert J
dc.contributor.authorde Bari, Cosimo
dc.contributor.authorCawthorn, William P
dc.contributor.authorHan, Weiping
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorRochford, Justin J.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.date.accessioned2018-05-02T12:55:08Z
dc.date.available2018-05-02T12:55:08Z
dc.date.issued2018-04-01
dc.descriptionAcknowledgements: The authors would like to thank Dr Cristian Olarte-Sanchez for his help with metabolic studies, James Redmore and James Thorburn for their contributions to data collection and analysis, Alison Richmond, Susan Clark and Ausra Lionikiene for technical support, and staff at the University of Aberdeen's Medical Research Facility and Microscopy & Histology Facility. We are very grateful for the gift of the Adiponectin-Cre mice from Dr. Evan Rosen (Beth Israel Deaconess Medical Centre and Harvard Medical School, Boston, USA). Work was supported by the Medical Research Council (GDM/JJR; MR/L002620/1, MC/PC/15077, KS/WPC; MR/M021394/1, AJR/CDB; MR/L022893/1), the Biotechnology and Biological Sciences Research Council (JJR; BB/K017772/1), the British Heart Foundation (MD; PG/14/43/30889, KS/WPC; BHF CoRE Bioinformatics Grant), NHS Grampian Endowments (AJR/CDB/JJR; Grant No. 16/11/032) and the NHS Grampian Rheumatology Department.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1949543
dc.identifier115417286
dc.identifierf55e15f3-10d7-4b73-a58e-46c88fa5a584
dc.identifier85042070782
dc.identifier.citationMcIlroy, G, Suchacki, K, Roelofs, A J, Yang, W, Fu, Y, Bai, B, Wallace, R J, de Bari, C, Cawthorn, W P, Han, W, Delibegovic, M & Rochford, J J 2018, 'Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease', Molecular Metabolism, vol. 10, pp. 55-65. https://doi.org/10.1016/j.molmet.2018.01.019en
dc.identifier.doi10.1016/j.molmet.2018.01.019
dc.identifier.issn2212-8778
dc.identifier.otherORCID: /0000-0002-5020-4939/work/53729080
dc.identifier.otherORCID: /0000-0003-4230-4355/work/102133117
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847580
dc.identifier.urihttp://hdl.handle.net/2164/10405
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectBSCL2en
dc.subjectseipinen
dc.subjectCGL2en
dc.subjectlipodystrophyen
dc.subjectadipose tissueen
dc.subjectBrowningen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/L002620/1en
dc.subjectMC/PC/15077,en
dc.subjectMR/M021394/1en
dc.subjectMR/L022893/1en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/K017772/1en
dc.subjectBritish Heart Foundationen
dc.subjectPG/14/43/30889en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAdipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic diseaseen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
1_s2.0_S2212877817310700_main.pdf
Size:
1.86 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
8.29 KB
Format:
Plain Text
Description:
Download

Collections

All research
Applied Medicine research
Medical Sciences research
Rowett Institute Of Nutrition & Health research
University Office research