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High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease

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dc.contributor.authorArastoo, Mohammad
dc.contributor.authorPenny, Lewis Kirk
dc.contributor.authorLofthouse, Richard Andrew
dc.contributor.authorAbdallah, Aya
dc.contributor.authorAbrahamsson, Anna
dc.contributor.authorMarini, Pietro
dc.contributor.authorMelis, Valeria
dc.contributor.authorRiedel, Gernot
dc.contributor.authorHarrington, Charles
dc.contributor.authorWischik, Claude
dc.contributor.authorPorter, Andrew
dc.contributor.authorPalliyil, Soumya
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Neuroscienceen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Microbiology and Immunityen
dc.date.accessioned2024-10-21T12:13:01Z
dc.date.available2024-10-21T12:13:01Z
dc.date.issued2024-10-02
dc.descriptionWe would like to thank the South West Dementia Brain Bank (SWDBB) and donors for the human brain tissue provided for this study. We would like to acknowledge the University of Aberdeen core facilities of Microscopy and Histology, Iain Fraser Cytometry Centre, and Proteomics for their support with microscopy, flow cytometry and surface plasmon resonance, respectively.en
dc.description.statusPeer revieweden
dc.format.extent20
dc.format.extent5060569
dc.identifier292599214
dc.identifier5cc7fb80-74ef-4433-93d8-c42fcf8a0d65
dc.identifier85205526769
dc.identifier39358820
dc.identifier.citationArastoo, M, Penny, L K, Lofthouse, R A, Abdallah, A, Abrahamsson, A, Marini, P, Melis, V, Riedel, G, Harrington, C, Wischik, C, Porter, A & Palliyil, S 2024, 'High-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease', Alzheimer's Research & Therapy, vol. 16, 209. https://doi.org/10.1186/s13195-024-01561-1en
dc.identifier.doi10.1186/s13195-024-01561-1
dc.identifier.issn1758-9193
dc.identifier.otherORCID: /0000-0002-0805-4949/work/170011412
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415862
dc.identifier.otherORCID: /0000-0002-8456-4473/work/177758640
dc.identifier.urihttps://hdl.handle.net/2164/24444
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85205526769&partnerID=8YFLogxKen
dc.identifier.vol16en
dc.language.isoeng
dc.relation.ispartofAlzheimer's Research & Therapyen
dc.subjectSubstantive connection via an eligible employment contracten
dc.subjectAlzheimer’s diseaseen
dc.subjectTauopathyen
dc.subjectTau proteinen
dc.subjectPaired helical filamenten
dc.subjectMonoclonal antibodyen
dc.subjectDiagnosticen
dc.subjectTherapyen
dc.subjectImmunotherapyen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectSupplementary Informationen
dc.subjecthttps://static-content.springer.com/esm/art%3A10.1186%2Fs13195-024-01561-1/MediaObjects/13195_2024_1561_MOESM1_ESM.docxen
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subject.lccRC0321en
dc.titleHigh-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s diseaseen
dc.typeJournal articleen

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