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Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

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dc.contributor.authorShiells, Helen
dc.contributor.authorSchelter, Bjoern O.
dc.contributor.authorBentham, Peter
dc.contributor.authorBaddeley, Thomas C.
dc.contributor.authorRubino, Christopher M.
dc.contributor.authorGanesan, Harish
dc.contributor.authorHammel, Jeffrey
dc.contributor.authorVuksanovic, Vesna
dc.contributor.authorStaff, Roger T.
dc.contributor.authorMurray, Alison D.
dc.contributor.authorBracoud, Luc
dc.contributor.authorWischik, Damon J.
dc.contributor.authorRiedel, Gernot
dc.contributor.authorGauthier, Serge
dc.contributor.authorJia, Jianping
dc.contributor.authorMoebius, Hans J.
dc.contributor.authorHardlund, Jiri
dc.contributor.authorKipps, Christopher M.
dc.contributor.authorKook, Karin
dc.contributor.authorStorey, John M. D.
dc.contributor.authorHarrington, Charles R.
dc.contributor.authorWischik, Claude M.
dc.contributor.institutionUniversity of Aberdeen.Physicsen
dc.contributor.institutionUniversity of Aberdeen.Institute for Complex Systems and Mathematical Biology (ICSMB)en
dc.contributor.institutionUniversity of Aberdeen.Chemistryen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Centre for Health Data Scienceen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2020-06-02T11:20:01Z
dc.date.available2020-06-02T11:20:01Z
dc.date.issued2020-05-19
dc.descriptionFunding The study was sponsored by TauRx Therapeutics (Singapore). Acknowledgments We gratefully acknowledge study investigators and the generosity of study participants.en
dc.description.statusPeer revieweden
dc.format.extent19
dc.format.extent474195
dc.identifier159874087
dc.identifier07bef2f1-c82d-4a51-8c36-847cd5cabef0
dc.identifier32280089
dc.identifier32280089
dc.identifier85085265745
dc.identifier000541124200013
dc.identifier.citationShiells, H, Schelter, B O, Bentham, P, Baddeley, T C, Rubino, C M, Ganesan, H, Hammel, J, Vuksanovic, V, Staff, R T, Murray, A D, Bracoud, L, Wischik, D J, Riedel, G, Gauthier, S, Jia, J, Moebius, H J, Hardlund, J, Kipps, C M, Kook, K, Storey, J M D, Harrington, C R & Wischik, C M 2020, 'Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia', Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519. https://doi.org/10.3233/JAD-191173en
dc.identifier.doi10.3233/JAD-191173
dc.identifier.iss2en
dc.identifier.issn1387-2877
dc.identifier.otherORCID: /0000-0002-5261-5467/work/75444735
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976609
dc.identifier.otherORCID: /0000-0003-2250-3920/work/173415894
dc.identifier.urihttps://hdl.handle.net/2164/14427
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85085265745&partnerID=8YFLogxKen
dc.identifier.vol75en
dc.language.isoeng
dc.relation.ispartofJournal of Alzheimer's Diseaseen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectHydromethylthionineen
dc.subjectLeucomethylthioniniumen
dc.subjectBehavioural variant frontotemporal dementiaen
dc.subjectClinical trialsen
dc.subjectTau proteinen
dc.subjectTDP-43en
dc.subjectleucomethylthioniniumen
dc.subjecthydromethylthionineen
dc.subjectBehavioral variant frontotemporal dementiaen
dc.subjectclinical trialsen
dc.subjecttau proteinen
dc.subjectMETHYLENE-BLUEen
dc.subjectLOBAR DEGENERATIONen
dc.subjectALZHEIMERS-DISEASEen
dc.subjectSEROTONIN TOXICITYen
dc.subjectPICK BODIESen
dc.subjectAGGREGATION INHIBITOR THERAPYen
dc.subjectDOUBLE-BLINDen
dc.subjectTAU-AGGREGATIONen
dc.subjectDIAGNOSTIC-CRITERIAen
dc.subjectPROGRESSIONen
dc.subjectRC0321 Neuroscience. Biological psychiatry. Neuropsychiatryen
dc.subjectGeriatrics and Gerontologyen
dc.subjectPsychiatry and Mental healthen
dc.subjectClinical Psychologyen
dc.subjectGeneral Neuroscienceen
dc.subjectSupplementary Dataen
dc.subject.lccRC0321en
dc.titleConcentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementiaen
dc.typeJournal articleen

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