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Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales

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dc.contributor.authorKerr, Steven
dc.contributor.authorBedston, Stuart
dc.contributor.authorCezard, Genevieve
dc.contributor.authorSampri, Alexia
dc.contributor.authorMurphy, Siobhan
dc.contributor.authorBradley, Declan T
dc.contributor.authorMorrison, Kirsty
dc.contributor.authorAkbari, Ashley
dc.contributor.authorWhiteley, William
dc.contributor.authorSullivan, Christopher
dc.contributor.authorPatterson, Lynsey
dc.contributor.authorKhunti, Kamlesh
dc.contributor.authorDenaxas, Spiros
dc.contributor.authorBolton, Thomas
dc.contributor.authorKhan, Samaira
dc.contributor.authorKeys, Alan
dc.contributor.authorWeatherill, David
dc.contributor.authorMooney, Karen
dc.contributor.authorDavies, Jan
dc.contributor.authorRitchie, Lewis
dc.contributor.authorMcMenamin, Jim
dc.contributor.authorKee, Frank
dc.contributor.authorWood, Angela
dc.contributor.authorLyons, Ronan A
dc.contributor.authorSudlow, Cathie
dc.contributor.authorRobertson, Chris
dc.contributor.authorSheikh, Aziz
dc.contributor.authorThe HDR UK COALESCE Consortium
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.date.accessioned2024-07-16T13:46:01Z
dc.date.available2024-07-16T13:46:01Z
dc.date.issued2024-02-10
dc.descriptionWe thank Dave Kelly from Albasoft for his support with making primary care data available, and Lynn Morrice, Wendy Inglis Humphrey, and Laura Gonzalez Rienda for their support with project management and administration. This work uses data provided by patients and collected by the NHS as part of their care and support. We would also like to acknowledge all data providers who make anonymised data available for research. We wish to acknowledge the collaborative partnership that enabled acquisition and access to the de-identified data in Wales, which led to this output. The collaboration was led by the Swansea University Health Data Research UK team under the direction of the Welsh Government Technical Advisory Cell and includes the following groups and organisations: the Secure Anonymised Information Linkage Databank, Administrative Data Research Wales, NHS Wales Informatics Service, Public Health Wales, NHS Shared Services Partnership, and the Welsh Ambulance Service Trust. All research conducted has been completed under the permission and approval of the Secure Anonymised Information Linkage Independent Information Governance Review Panel (project number: 0911). We acknowledge the help provided by the staff of the Honest Broker Service (HBS) within the Business Services Organisation Northern Ireland (BSO). The HBS is funded by the BSO and the Department of Health. The authors alone are responsible for the interpretation of the data and any views or opinions presented are solely those of the author and do not necessarily represent those of the BSO. Research in Northern Ireland was conducted under approval by the HBS Governance Board approval number 064. KK is supported by the National Institute for Health Research Applied Research Collaboration East Midlands and Leicester Biomedical Research Centre. This work was supported by the UK Research and Innovation National Core Studies: Data and Connectivity (MC_PC_20029 or MC_PC_20058), with further support from Health Data Research UK (HDR UK), an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations, and leading medical research charities. This work was also carried out with the support of the BHF Data Science Centre at HDR UK (SP/19/3/34678). This study makes use of de-identified data held in NHS England's Secure Data Environment service for England and made available via the BHF Data Science Centre's CVD-COVID-UK/COVID-IMPACT consortium. The BHF Data Science Centre (grant No SP/19/3/34678, awarded to HDR UK) funded co-development (with NHS England) of the trusted research environment, provision of linked datasets, data access, user software licences, computational usage, and data management and wrangling support, with additional contributions from the HDR UK Data and Connectivity component of the UK Government Chief Scientific Adviser's National Core Studies programme to coordinate national COVID-19 priority research. Consortium partner organisations funded the time of contributing data analysts, biostatisticians, epidemiologists, and clinicians.en
dc.description.statusPeer revieweden
dc.format.extent13
dc.format.extent482726
dc.identifier283596157
dc.identifier984a846d-89a2-451a-a4e7-d9a9f87682b8
dc.identifier85183900344
dc.identifier.citationKerr, S, Bedston, S, Cezard, G, Sampri, A, Murphy, S, Bradley, D T, Morrison, K, Akbari, A, Whiteley, W, Sullivan, C, Patterson, L, Khunti, K, Denaxas, S, Bolton, T, Khan, S, Keys, A, Weatherill, D, Mooney, K, Davies, J, Ritchie, L, McMenamin, J, Kee, F, Wood, A, Lyons, R A, Sudlow, C, Robertson, C, Sheikh, A & The HDR UK COALESCE Consortium 2024, 'Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales', The Lancet, vol. 403, no. 10426, pp. 554-566. https://doi.org/10.1016/S0140-6736(23)02467-4en
dc.identifier.doi10.1016/S0140-6736(23)02467-4
dc.identifier.iss10426en
dc.identifier.issn0140-6736
dc.identifier.otherRIS: urn:DD833E1285D4E77509ECFF253F9CD246
dc.identifier.urihttps://hdl.handle.net/2164/23826
dc.identifier.vol403en
dc.language.isoeng
dc.relation.ispartofThe Lanceten
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectR Medicineen
dc.subjectUK Research and Innovation (UKRI)en
dc.subjectMC_PC_20029en
dc.subjectMC_PC_20058en
dc.subjectBritish Heart Foundationen
dc.subjectSP/19/3/34678en
dc.subjectSupplementary Informationen
dc.subjecthttps://ars.els-cdn.com/content/image/1-s2.0-S0140673623024674-mmc1.pdfen
dc.subject.lccRen
dc.titleUndervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Walesen
dc.typeJournal articleen

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