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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

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dc.contributor.authorHamilton, Olivia K L
dc.contributor.authorZhang, Qian
dc.contributor.authorMcRae, Allan F
dc.contributor.authorWalker, Rosie M
dc.contributor.authorMorris, Stewart W
dc.contributor.authorRedmond, Paul
dc.contributor.authorCampbell, Archie
dc.contributor.authorMurray, Alison D
dc.contributor.authorPorteous, David J
dc.contributor.authorEvans, Kathryn L
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorDeary, Ian J
dc.contributor.authorMarioni, Riccardo E
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Grampian Data Safe Haven (DaSH)en
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Biomedical Imaging Centreen
dc.date.accessioned2019-03-28T15:00:05Z
dc.date.available2019-03-28T15:00:05Z
dc.date.issued2019-03-06
dc.descriptionAcknowledgements: The authors thank all LBC study participants and research team members who have contributed, and continue to contribute, to the ongoing LBC study. The LBC1936 is supported by Age UK (Disconnected Mind programme) and the Medical Research Council [MR/M01311/1]. The LBC1921 is supported by the Biotechnology and Biological Sciences Research Council [SR176], the Chief Scientist Office [CZB/4/505; ETM/55] and the Medical Research Council [R42550]. Methylation typing was supported by the Centre for Cognitive Ageing and Cognitive Epidemiology (Pilot Fund award), Age UK, The Wellcome Trust Institutional Strategic Support Fund, The University of Edinburgh, and The University of Queensland. This work was conducted in the Centre for Cognitive Ageing and Cognitive Epidemiology, which is supported by the Medical Research Council and Biotechnology and Biological Sciences Research Council [MR/K026992/1], and which supports Ian Deary. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates [CZD/16/6] and the Scottish Funding Council [HR03006]. Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Wellcome Trust Clinical Research Facility, Edinburgh, Scotland, and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” [(STRADL) 104036/Z/14/Z])en
dc.description.statusPeer revieweden
dc.format.extent8
dc.format.extent572505
dc.identifier142569640
dc.identifier8d18f249-9794-48e1-bf1e-a9cae1c10975
dc.identifier30842548
dc.identifier85062630117
dc.identifier000484358100014
dc.identifier.citationHamilton, O K L, Zhang, Q, McRae, A F, Walker, R M, Morris, S W, Redmond, P, Campbell, A, Murray, A D, Porteous, D J, Evans, K L, McIntosh, A M, Deary, I J & Marioni, R E 2019, 'An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort', International Journal of Obesity, vol. 43, pp. 1795-1802. https://doi.org/10.1038/s41366-018-0262-3en
dc.identifier.doi10.1038/s41366-018-0262-3
dc.identifier.issn0307-0565
dc.identifier.otherMendeley: 947ae41d-1df9-31c6-a1f9-7f425dbb9533
dc.identifier.otherORCID: /0000-0003-4915-4847/work/76976602
dc.identifier.urihttp://hdl.handle.net/2164/12092
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85062630117&partnerID=8YFLogxKen
dc.identifier.urlhttp://www.mendeley.com/research/epigenetic-score-bmi-based-dna-methylation-correlates-poor-physical-health-major-disease-lothian-biren
dc.identifier.vol43en
dc.language.isoeng
dc.relation.ispartofInternational Journal of Obesityen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectFOOD-FREQUENCY QUESTIONNAIREen
dc.subjectEPIGENOME-WIDE ASSOCIATIONen
dc.subjectBODY-MASS INDEXen
dc.subjectWEIGHT-LOSSen
dc.subjectLIFEen
dc.subjectVALIDITYen
dc.subjectPATTERNSen
dc.subjectOBESEen
dc.subjectHIF3Aen
dc.subjectR Medicineen
dc.subjectNutrition and Dieteticsen
dc.subjectMedicine (miscellaneous)en
dc.subjectEndocrinology, Diabetes and Metabolismen
dc.subjectScottish Funding Councilen
dc.subjectHR03006en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/M01311/1en
dc.subjectMR/K026992/1en
dc.subjectR42550en
dc.subjectChief Scientist Office (CSO)en
dc.subjectCZD/16/6en
dc.subjectETM/55en
dc.subjectCZB/4/505en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectMR/K026992/1en
dc.subjectSR176en
dc.subjectWellcome Trusten
dc.subject(STRADL) 104036/Z/14/Zen
dc.subjectSupplementary Dataen
dc.subjectSupplementary data availableen
dc.subject.lccRen
dc.titleAn epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohorten
dc.typeJournal articleen

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