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Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trial

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dc.contributor.authorMorrow, Gael B.
dc.contributor.authorFeller, Timea
dc.contributor.authorMcQuilten, Zoe
dc.contributor.authorWake, Elizabeth
dc.contributor.authorAriëns, Robert A. S.
dc.contributor.authorWinearls, James
dc.contributor.authorMutch, Nicola J.
dc.contributor.authorLaffan, Mike A.
dc.contributor.authorCurry, Nicola
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Cardiometabolic Diseaseen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2022-10-02T20:24:01Z
dc.date.available2022-10-02T20:24:01Z
dc.date.issued2022-09-26
dc.descriptionAcknowledgements We acknowledge the Aberdeen Microscopy and Histology Core Facility and thank Judith de Vries for her guidance in analysing the confocal images. We thank Megan Simpson for measuring PAI-1 and uPA antigen levels in the fibrinogen preparations. We thank all of the FEISTY research staff who collected and processed the patient samples. Funding This work was supported by research grants from CSL Behring and Tenovus Scotland.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent2371013
dc.identifier219655238
dc.identifier86079961-1b3f-4f0c-bba9-f75db039d2eb
dc.identifier36163263
dc.identifier85138655795
dc.identifier.citationMorrow, G B, Feller, T, McQuilten, Z, Wake, E, Ariëns, R A S, Winearls, J, Mutch, N J, Laffan, M A & Curry, N 2022, 'Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trial', Critical Care, vol. 26, no. 1, 290. https://doi.org/10.1186/s13054-022-04167-xen
dc.identifier.doi10.1186/s13054-022-04167-x
dc.identifier.iss1en
dc.identifier.issn1364-8535
dc.identifier.otherRIS: urn:474282ECCD3E9944BD3ECAAFBF31EB93
dc.identifier.otherRIS: Morrow2022
dc.identifier.otherORCID: /0000-0001-9299-6754/work/120222482
dc.identifier.otherORCID: /0000-0002-7452-0813/work/169538898
dc.identifier.urihttps://hdl.handle.net/2164/19263
dc.identifier.vol26en
dc.language.isoeng
dc.relation.ispartofCritical Careen
dc.subjectFibrinogenen
dc.subjectcryoprecipitateen
dc.subjectclot structureen
dc.subjectTrauma coagulopathyen
dc.subjectfibrinolysisen
dc.subjectR Medicine (General)en
dc.subjectSupplementary Informationen
dc.subjectSupplementary Dataen
dc.subjectDASen
dc.subject.lccR1en
dc.titleCryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability : Results from a laboratory sub-study of the FEISTY trialen
dc.typeJournal articleen

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