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Glucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection

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dc.contributor.authorLarcombe, Daniel E
dc.contributor.authorBohovych, Iryna M
dc.contributor.authorPradhan, Arnab
dc.contributor.authorMa, Qinxi
dc.contributor.authorHickey, Emer
dc.contributor.authorLeaves, Ian
dc.contributor.authorCameron, Gary
dc.contributor.authorAvelar, Gabriela M
dc.contributor.authorde Assis, Leandro J
dc.contributor.authorChilders, Delma S
dc.contributor.authorBain, Judith M
dc.contributor.authorLagree, Katherine
dc.contributor.authorMitchell, Aaron P
dc.contributor.authorNetea, Mihai G
dc.contributor.authorErwig, Lars P
dc.contributor.authorGow, Neil A R
dc.contributor.authorBrown, Alistair J P
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.date.accessioned2023-08-07T16:03:01Z
dc.date.available2023-08-07T16:03:01Z
dc.date.issued2023-07-10
dc.descriptionAcknowledgments We thank Carol Munro for her generosity in providing the plasmids for barcoding C. albicans, and Victoria Brown, Gerry Fink, Bill Fonzi, Guanghua Huang, Joachim Morschauser, Suzanne Noble, Jesus Pla, Patrick Van Dijck, Reinhard Würzner and Oscar Zaragoza for providing strains. We thank our colleagues in the MRC Centre for Medical Mycology and the Aberdeen Fungal Group for insightful discussions. We are grateful to the following Research Facilities for their advice and support: the Centre for Genome Enabled Biology at the University of Aberdeen, and the Sequencing Facility at the University of Exeter for help with the barcode sequencing. Funding: This work was funded by a programme grant to AJPB, NARG, LEP and MGN from the UK Medical Research Council [www.mrc.ac.uk: MR/M026663/1, MR/M026663/2] and by PhD studentships to DEL from the Universities of Aberdeen and Exeter. The work was also supported by the Medical Research Council Centre for Medical Mycology (MR/N006364/1, MR/N006364/2). NARG acknowledges Wellcome support of Senior Investigator (101873/Z/13/Z, 224323/Z/21/Z) and Collaborative (200208/A/15/Z, 215599/Z/19/Z) Awards. MGN was supported by an ERC Advanced Grant (833247) and a Spinoza Grant of the Netherlands Organization for Scientific Research. The barcode sequencing performed by the Exeter Sequencing Facility utilised equipment funded by Wellcome (218247/Z/19/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent2810809
dc.identifier269843356
dc.identifierbb58b7ae-852e-45da-8756-2f480dd3b1f6
dc.identifier37428810
dc.identifier85165636651
dc.identifier.citationLarcombe, D E, Bohovych, I M, Pradhan, A, Ma, Q, Hickey, E, Leaves, I, Cameron, G, Avelar, G M, de Assis, L J, Childers, D S, Bain, J M, Lagree, K, Mitchell, A P, Netea, M G, Erwig, L P, Gow, N A R & Brown, A J P 2023, 'Glucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection', PLoS Pathogens, vol. 19, no. 7, pp. e1011505. https://doi.org/10.1371/journal.ppat.1011505en
dc.identifier.doi10.1371/journal.ppat.1011505
dc.identifier.iss7en
dc.identifier.issn1553-7366
dc.identifier.otherPubMedCentral: PMC10358912
dc.identifier.otherORCID: /0000-0003-2869-7332/work/140032230
dc.identifier.otherORCID: /0000-0002-3977-6733/work/159078589
dc.identifier.urihttps://hdl.handle.net/2164/21421
dc.identifier.vol19en
dc.language.isoeng
dc.relation.ispartofPLoS Pathogensen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/M026663/1en
dc.subjectMR/M026663/2en
dc.subjectMR/N006364/1en
dc.subjectMR/N006364/2)en
dc.subjectWellcome Trusten
dc.subject101873/Z/13/Zen
dc.subject224323/Z/21/Zen
dc.subject218247/Z/19/Zen
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleGlucose-enhanced oxidative stress resistance-A protective anticipatory response that enhances the fitness of Candida albicans during systemic infectionen
dc.typeJournal articleen

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