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A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs

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dc.contributor.authorEijlers, Peter
dc.contributor.authorAl-Khafaji, Mohammed Ismael
dc.contributor.authorSoto Martin, Eva
dc.contributor.authorFasimoye, Rotimi Yemi
dc.contributor.authorStead, David
dc.contributor.authorWenzel, Marius
dc.contributor.authorMuller, Berndt
dc.contributor.authorPettitt, Jonathan
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Molecular and Cellular Functionen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2024-06-18T15:45:01Z
dc.date.available2024-06-18T15:45:01Z
dc.date.issued2024-07-08
dc.descriptionAcknowledgements We thank Maheshika Kurukulasuriya for her assistance with immunoprecipitations from embryo extracts. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). Sequencing was performed by the Centre for Genome-Enabled Biology and Medicine of the University of Aberdeen, and proteomics analysis by the Aberdeen proteomics facility. We thank Kate Burgoyne and Craig Pattinson (Aberdeen Proteomics) for technical support. We thank WormBase for providing the community resource that facilitated the interrogation of C. elegans molecular genetics used in this work . Author contribution: P.E., M.A., E.S.-M., R.F., M.W., B.M. and J.P. contributed experiments. J.P. and B.M. conceived the research and managed and coordinated the research activity; J.P. and B.M. acquired funding for the project; D.S. guided the proteomics analysis, M.W., B.M. and J.P. designed and implemented the computational analysis; M.W., B.M. and J.P. wrote the manuscript and prepared figures and tables.en
dc.description.statusPeer revieweden
dc.format.extent16
dc.format.extent2192019
dc.identifier288782796
dc.identifiere59362a0-614f-44fe-ad5f-48014c57ed36
dc.identifier85197968231
dc.identifier38676950
dc.identifier.citationEijlers, P, Al-Khafaji, M I, Soto Martin, E, Fasimoye, R Y, Stead, D, Wenzel, M, Muller, B & Pettitt, J 2024, 'A nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAs', Nucleic Acids Research, vol. 52, no. 12, gkae321, pp. 7245-7260. https://doi.org/10.1093/nar/gkae321en
dc.identifier.doi10.1093/nar/gkae321
dc.identifier.iss12en
dc.identifier.issn0305-1048
dc.identifier.otherORCID: /0000-0003-1279-5421/work/159077956
dc.identifier.otherORCID: /0000-0001-9268-5868/work/159077960
dc.identifier.otherORCID: /0000-0003-0093-368X/work/159078016
dc.identifier.otherORCID: /0000-0001-7988-6833/work/160389546
dc.identifier.otherORCID: /0009-0009-3364-1174/work/188340731
dc.identifier.urihttps://hdl.handle.net/2164/23650
dc.identifier.urlhttps://abdn.elsevierpure.com/en/publications/e59362a0-614f-44fe-ad5f-48014c57ed36en
dc.identifier.vol52en
dc.language.isoeng
dc.relation.ispartofNucleic Acids Researchen
dc.subjectAnimalsen
dc.subjectRNA, Spliced Leader/metabolismen
dc.subjectRNA Precursors/metabolismen
dc.subjectRibonucleoproteins, Small Nuclear/metabolismen
dc.subjectSpliceosomes/metabolismen
dc.subjectCaenorhabditis elegans/geneticsen
dc.subjectCaenorhabditis elegans Proteins/metabolismen
dc.subjectTrans-Splicingen
dc.subjectProtein Bindingen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/T002859/1en
dc.subjectSupplementary Dataen
dc.subjecthttps://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkae321#supplementary-dataen
dc.subject.lccRen
dc.titleA nematode-specific ribonucleoprotein complex mediates interactions between the major nematode spliced leader snRNP and its target pre-mRNAsen
dc.typeJournal articleen

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