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Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy : a multicentre, parallel, randomised, controlled, phase 3 trial

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dc.contributor.authorTurner, Steve
dc.contributor.authorCotton, Seonaidh
dc.contributor.authorWood, Jessica
dc.contributor.authorBell, Victoria
dc.contributor.authorRaja, Edwin Amalraj
dc.contributor.authorScott, Neil
dc.contributor.authorMorgan, Heather
dc.contributor.authorLawrie, Louisa
dc.contributor.authorEmele, David
dc.contributor.authorKennedy, Charlotte
dc.contributor.authorScotland, Graham
dc.contributor.authorFielding, Shona
dc.contributor.authorMacLennan, Graeme
dc.contributor.authorNorrie, John
dc.contributor.authorForrest, Mark
dc.contributor.authorGaillard, Erol A.
dc.contributor.authorde Jongste, Johan C.
dc.contributor.authorPijnenburg, Mariëlle W
dc.contributor.authorThomas, Mike
dc.contributor.authorPrice, David
dc.contributor.institutionUniversity of Aberdeen.Other Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Medical Statisticsen
dc.contributor.institutionUniversity of Aberdeen.Institute of Applied Health Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Centre for Health Data Scienceen
dc.contributor.institutionUniversity of Aberdeen.Health Economics Research Uniten
dc.date.accessioned2022-11-30T00:07:04Z
dc.date.available2022-11-30T00:07:04Z
dc.date.embargoedUntil2022-11-30
dc.date.issued2022-06-06
dc.descriptionACKNOWLEDGEMENTS We would like to thank all the children who took part in the study and their families. We are grateful to all the staff at recruitment sites that facilitated identification, recruitment and follow-up of study participants (listed below). We could not have completed the study without the ongoing support of local and primary care research networks. We are grateful for the primary care practices that acted as Participant Identification Centres and to the National Research Scotland Primary Care Network for facilitating this activity. The authors express their thanks to the staff in the primary care centres who provided primary outcome data. We are grateful to Andrea Fraser for her secretarial and data co-ordination support. We are grateful to Ruth Thomas for her help and advice in developing the grant proposal. We thank the Programming Team in CHaRT for developing and maintaining the study website and David Cooper for his statistical analysis advice. We also thank Juliette Snow and Rachael West for their help with contracting, and to Louise Cotterell, Helen Strachan, Blair Annandale and Anne Buckle for their help in managing the budget. We are very grateful for Dr Aileen Neilson for her work in establishing the Health Economic methodology. We also thank the Research Governance team (Louise King, Stacey Dawson, Lynn McKay) at the University of Aberdeen for their advice and support during the study. We acknowledge the funding provided by the National Institute of Health Research Efficacy and Mechanism Evaluation (Ref 15-18-14)en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent1335937
dc.identifier202313958
dc.identifier44045b04-a325-4393-9573-e8297b9fb54e
dc.identifier85124876720
dc.identifier85124876720
dc.identifier35101183
dc.identifier.citationTurner, S, Cotton, S, Wood, J, Bell, V, Raja, E A, Scott, N, Morgan, H, Lawrie, L, Emele, D, Kennedy, C, Scotland, G, Fielding, S, MacLennan, G, Norrie, J, Forrest, M, Gaillard, E A, de Jongste, J C, Pijnenburg, M W, Thomas, M & Price, D 2022, 'Reducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy : a multicentre, parallel, randomised, controlled, phase 3 trial', The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592. https://doi.org/10.1016/S2213-2600(21)00486-0en
dc.identifier.doi10.1016/S2213-2600(21)00486-0
dc.identifier.iss6en
dc.identifier.issn2213-2600
dc.identifier.otherORCID: /0000-0002-6118-8911/work/110637495
dc.identifier.otherORCID: /0000-0002-1039-5646/work/110637838
dc.identifier.otherORCID: /0000-0002-8067-9660/work/110638391
dc.identifier.otherORCID: /0000-0003-0853-9724/work/162727494
dc.identifier.urihttps://hdl.handle.net/2164/19642
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85124876720&partnerID=8YFLogxKen
dc.identifier.vol10en
dc.language.isoeng
dc.relation.ispartofThe Lancet. Respiratory medicineen
dc.subjectAlgorithmsen
dc.subjectasthmaen
dc.subjectchilden
dc.subjectClinical trialen
dc.subjectNitric Oxideen
dc.subjectTherapeuticsen
dc.subjectR Medicineen
dc.subjectPulmonary and Respiratory Medicineen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subject15-18-14en
dc.subject.lccRen
dc.titleReducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy : a multicentre, parallel, randomised, controlled, phase 3 trialen
dc.typeJournal articleen

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