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A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast

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dc.contributor.authorReed, Austin D
dc.contributor.authorPensa, Sara
dc.contributor.authorSteif, Adi
dc.contributor.authorStenning, Jack
dc.contributor.authorKunz, Daniel J
dc.contributor.authorPorter, Linsey J
dc.contributor.authorHua, Kui
dc.contributor.authorHe, Peng
dc.contributor.authorTwigger, Alecia-Jane
dc.contributor.authorSiu, Abigail J Q
dc.contributor.authorKania, Katarzyna
dc.contributor.authorBarrow-McGee, Rachel
dc.contributor.authorGoulding, Iain
dc.contributor.authorGomm, Jennifer J
dc.contributor.authorSpeirs, Valerie
dc.contributor.authorJones, J Louise
dc.contributor.authorMarioni, John C
dc.contributor.authorKhaled, Walid T
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cancer Centreen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2024-04-25T11:14:00Z
dc.date.available2024-04-25T11:14:00Z
dc.date.issued2024-04
dc.descriptionA.D.R. performed the majority of the bioinformatic analysis and interpretation of the data. S.P. contributed to the study design, sample processing, analysis and interpretation of the data. J.S. contributed to the sample processing. D.J.K. and P.H. contributed to the data processing, batch correction and cell cluster identification. A.S. contributed to the design of the sample batches and contributed to the analysis of the raw data. A.J.T. contributed to the analysis of the data and Figure design. L.J.P. performed the immune histochemistry validations. K.H. assisted A.D.R. with the inferCNV analysis and interpretation. P.H. assisted with the subclustering of immune cells and scVI integration analysis. A.Q.S. performed the immunofluorescence quantification. K.K. performed all the scRNA-seq library preparation and sequencing. R.B.M., I.G., J.J.G., V.S. and J.L.J. provided the human tissues and the metadata from the 55 donors. A.D.R., S.P., J.C.M. and W.T.K. wrote the paper. J.C.M. and W.T.K. conceptualized and supervised the study.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent18704374
dc.identifier288951451
dc.identifier7c3c0983-3f40-4b1d-b050-aecb0a49fe8d
dc.identifier38548988
dc.identifier85188941203
dc.identifier.citationReed, A D, Pensa, S, Steif, A, Stenning, J, Kunz, D J, Porter, L J, Hua, K, He, P, Twigger, A-J, Siu, A J Q, Kania, K, Barrow-McGee, R, Goulding, I, Gomm, J J, Speirs, V, Jones, J L, Marioni, J C & Khaled, W T 2024, 'A single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast', Nature Genetics, vol. 56, no. 4, pp. 652-662. https://doi.org/10.1038/s41588-024-01688-9en
dc.identifier.doi10.1038/s41588-024-01688-9
dc.identifier.iss4en
dc.identifier.issn1061-4036
dc.identifier.otherORCID: /0000-0002-0602-4666/work/158672372
dc.identifier.urihttps://hdl.handle.net/2164/23344
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85188941203&partnerID=8YFLogxKen
dc.identifier.vol56en
dc.language.isoeng
dc.relation.ispartofNature Geneticsen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAdulten
dc.subjectBRCA1 Protein/geneticsen
dc.subjectBRCA2 Protein/geneticsen
dc.subjectBreast Neoplasms/geneticsen
dc.subjectFemaleen
dc.subjectGenes, BRCA2en
dc.subjectGerm-Line Mutationen
dc.subjectHumansen
dc.subjectPregnancyen
dc.subjectR Medicine (General)en
dc.subjectGeneticsen
dc.subjectSupplementary Dataen
dc.subject.lccR1en
dc.titleA single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breasten
dc.typeJournal articleen

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