University of Aberdeen logo

AURA - Aberdeen University Research Archive

 

GDF15 promotes weight loss by enhancing energy expenditure in muscle

Simple item page
dc.contributor.authorWang, Dongdong
dc.contributor.authorTownsend, Logan K.
dc.contributor.authorDesOrmeaux, Geneviève J.
dc.contributor.authorFrangos, Sara M.
dc.contributor.authorBatchuluun, Battsetseg
dc.contributor.authorDumont, Lauralyne
dc.contributor.authorKuhre, Rune Ehrenreich
dc.contributor.authorAhmadi, Elham
dc.contributor.authorHu, Sumei
dc.contributor.authorRebalka, Irena A.
dc.contributor.authorGautam, Jaya
dc.contributor.authorJabile, Maria Joy Therese
dc.contributor.authorPileggi, Chantal A.
dc.contributor.authorRehal, Sonia
dc.contributor.authorDesjardins, Eric M.
dc.contributor.authorTsakiridis, Evangelia E.
dc.contributor.authorLally, James S.V.
dc.contributor.authorJuracic, Emma Sara
dc.contributor.authorTupling, A. Russell
dc.contributor.authorGerstein, Hertzel C.
dc.contributor.authorParé, Guillaume
dc.contributor.authorTsakiridis, Theodoros
dc.contributor.authorHarper, Mary Ellen
dc.contributor.authorHawke, Thomas J.
dc.contributor.authorSpeakman, John R.
dc.contributor.authorBlondin, Denis P.
dc.contributor.authorHolloway, Graham P.
dc.contributor.authorJørgensen, Sebastian Beck
dc.contributor.authorSteinberg, Gregory R.
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Environment and Food Securityen
dc.contributor.institutionUniversity of Aberdeen.Energetics Research Groupen
dc.date.accessioned2023-08-31T12:34:00Z
dc.date.available2023-08-31T12:34:00Z
dc.date.issued2023-07-06
dc.descriptionFunding Information: We thank R. Seeley for sharing GFRAL-null mice; B. Lowell for sharing β-less mice; and J. Wu for shipping β-less mice to us. G.R.S. was supported by a Diabetes Canada Investigator Award (DI-5-17-5302-GS), a Canadian Institutes of Health Research Foundation Grant (201709FDN-CEBA-116200), a Tier 1 Canada Research Chair in Metabolic Diseases and a J. Bruce Duncan Endowed Chair in Metabolic Diseases; D.W. by Fellowship Grants from the McMaster Institute for Research on Aging (MIRA) at McMaster University; S.R. by a postdoctoral fellowship supported by MITACS and Novo Nordisk; L.K.T. by a CIHR Post-Doctoral Fellowship Award and Michael DeGroote Fellowship Award in Basic Biomedical Science; E.M.D. by a Vanier Canada Graduate Scholarship; G.P.H. by the Natural Sciences and Engineering Research Council of Canada (NSERC: 400362); G.J.D. and S.M.F. by NSERC-CGSM scholarships; L.D. by the Fonds de Recherche du Québec-Santé doctoral training award; D.P.B. by the GSK Chair in Diabetes of Université de Sherbrooke and a FRQS J1 salary award. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by the NCI, NHGRI, NHLBI, NIDA, NIMH and NINDS. Funding Information: S.B.J. and R.E.K. are employees of Novo Nordisk, a pharmaceutical company producing and selling medicine for the treatment of diabetes and obesity. G.R.S. is a co-founder and shareholder of Espervita Therapeutics. McMaster University has received funding from Espervita Therapeutics, Esperion Therapeutics, Poxel Pharmaceuticals and Nestle for research conducted in the laboratory of G.R.S. S.R. is supported by a MITACS postdoctoral fellowship sponsored by Novo Nordisk. H.C.G. holds the McMaster-Sanofi Population Health Institute Chair in Diabetes Research and Care. G.R.S., G.P. and H.C.G. are inventors listed on a patent for identifying GDF15 as a biomarker for metformin. G.R.S. has received consulting/speaking fees from Astra Zeneca, Eli Lilly, Esperion Therapeutics, Merck, Poxel Pharmaceuticals and Cambrian Biosciences. The other authors declare no competing interests. Publisher Copyright: © 2023, The Author(s).en
dc.description.statusPeer revieweden
dc.format.extent8
dc.format.extent27171259
dc.identifier273879997
dc.identifiera5500dd7-7e81-4a70-8f39-3a5edb6ec2b5
dc.identifier85163624582
dc.identifier37380764
dc.identifier.citationWang, D, Townsend, L K, DesOrmeaux, G J, Frangos, S M, Batchuluun, B, Dumont, L, Kuhre, R E, Ahmadi, E, Hu, S, Rebalka, I A, Gautam, J, Jabile, M J T, Pileggi, C A, Rehal, S, Desjardins, E M, Tsakiridis, E E, Lally, J S V, Juracic, E S, Tupling, A R, Gerstein, H C, Paré, G, Tsakiridis, T, Harper, M E, Hawke, T J, Speakman, J R, Blondin, D P, Holloway, G P, Jørgensen, S B & Steinberg, G R 2023, 'GDF15 promotes weight loss by enhancing energy expenditure in muscle', Nature, vol. 619, no. 7968, pp. 143-150. https://doi.org/10.1038/s41586-023-06249-4en
dc.identifier.doi10.1038/s41586-023-06249-4
dc.identifier.iss7968en
dc.identifier.issn0028-0836
dc.identifier.urihttps://hdl.handle.net/2164/21601
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85163624582&partnerID=8YFLogxKen
dc.identifier.vol619en
dc.language.isoeng
dc.relation.ispartofNatureen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectDiabetesen
dc.subjectfat metabolismen
dc.subjectobesityen
dc.subjectrecombinant protein therapyen
dc.subjectR Medicineen
dc.subjectGeneralen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleGDF15 promotes weight loss by enhancing energy expenditure in muscleen
dc.typeJournal articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Wang_etal_N_GDF15_Promotes_Weight_VOR.pdf
Size:
25.91 MB
Format:
Adobe Portable Document Format
Download

Collections

All research

The Sir Duncan Rice Library

University of Aberdeen

Bedford Road

Aberdeen

AB24 3AA


Tel: +44 (0)1224 273330

Email: library@abdn.ac.uk

Share and keep up to date


FacebookTwitterWordpress