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A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

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dc.contributor.authorSolano-Collado, Virtu
dc.contributor.authorColamarino, Rosa Angela
dc.contributor.authorCalderwood, David A.
dc.contributor.authorBaldassarre, Massimiliano
dc.contributor.authorSpanò, Stefania
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.date.accessioned2021-04-08T11:30:01Z
dc.date.available2021-04-08T11:30:01Z
dc.date.issued2021-04-07
dc.descriptionAcknowledgments We are very grateful to Leigh Knodler for her generous gift of P22 phages from a S. Typhimurium glmS::Cm::mCherry strain. We thank the Microscopy and Histology Core Facility, the Centre for Genome-Enabled Biology and Medicine (CGEBM), the Iain Fraser Cytometry Centre and the qPCR Facility (University of Aberdeen) for their support and assistance in this work. We thank members of the Spanò/Baldassarre laboratory for their feedback throughout this project. The content of this manuscript has been posted as a preprint on bioRxiv (Solano-Collado et al., 2020). Funding This work was supported by the European Union’s Horizon 2020 research and innovation program Marie Skłodowska-Curie Fellowship (706040_KILLINGTYPHI) to VS-C, the Wellcome Trust (Seed Award 109680/Z/15/Z), the European Union’s Horizon 2020 ERC consolidator award (2016-726152-TYPHI), the BBSRC (BB/N017854/1) and Tenovus Scotland (G14/19) to SS.en
dc.description.statusPeer revieweden
dc.format.extent9
dc.format.extent1825006
dc.identifier191212710
dc.identifier78270a1e-48a9-48f5-b726-7462122c6d8a
dc.identifier85104639424
dc.identifier33898333
dc.identifier000641711200001
dc.identifier.citationSolano-Collado, V, Colamarino, R A, Calderwood, D A, Baldassarre, M & Spanò, S 2021, 'A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth', Frontiers in cellular and infection microbiology, vol. 11, 660689. https://doi.org/10.3389/fcimb.2021.660689en
dc.identifier.doi10.3389/fcimb.2021.660689
dc.identifier.issn2235-2988
dc.identifier.otherBibtex: 10.3389/fcimb.2021.660689
dc.identifier.otherORCID: /0000-0003-1035-2846/work/93483056
dc.identifier.otherORCID: /0000-0002-2498-4767/work/93483180
dc.identifier.otherORCID: /0000-0001-9171-2684/work/141719562
dc.identifier.urihttps://hdl.handle.net/2164/16200
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.660689/full#supplementary-materialen
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofFrontiers in cellular and infection microbiologyen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjecthost-defenseen
dc.subjectSalmonella Typhien
dc.subjectRab GTPasesen
dc.subjectRab1ben
dc.subjectshRNA screenen
dc.subjectmacrophagesen
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/N017854/1en
dc.subjectWellcome Trusten
dc.subject109680/Z/15/Zen
dc.subjectEuropean Commissionen
dc.subject706040_KILLINGTYPHIen
dc.subjectOtheren
dc.subject2016-726152-TYPHIen
dc.subjectG14/19en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleA Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growthen
dc.typeJournal articleen

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