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CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake

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dc.contributor.authorMcewan, Andrew
dc.contributor.authorHay, Elisabeth
dc.contributor.authorDavidson, Connor
dc.contributor.authorTurnbull, Yvonne
dc.contributor.authorErickson, Johanna Celene
dc.contributor.authorMarini, Pietro
dc.contributor.authorWilson, Dana
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorAdams, Mark J.
dc.contributor.authorMurgatroyd, Chris
dc.contributor.authorBarrett, Perry
dc.contributor.authorDelibegovic, Mirela
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorMacKenzie, Alasdair
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciences - Cardiovascular Groupen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2021-02-10T14:01:01Z
dc.date.available2021-02-10T14:01:01Z
dc.date.issued2019-12-13
dc.descriptionAcknowledgements We would like to thank Wenlong Huang, Giuseppe D’Agostino and the staff of the University of Aberdeen Medical Research Facility for their help and advice with the animal tests. AMcE was funded by BBSRC project grant (BB/N017544/1) and EH was funded by Medical Research Scotland (PhD-719-2013). PB and DW are funded by the Scottish Government Rural and Environment Science and Analytical Services Division to the Rowett Institute. Association studies were conducted using the UK Biobank Resource: application number 4844 and was supported by a Wellcome Trust Strategic Award ‘Stratifying Resilience and Depression Longitudinally’ (STRADL) (Reference 104036/Z/14/Z). Dedicated to the memory of my brother Angus MacKenzie (1963-2018).en
dc.description.statusNon peer revieweden
dc.format.extent36
dc.format.extent1544019
dc.identifier156320652
dc.identifier3711b325-d821-4a73-bf8e-588cf9229378
dc.identifier.citationMcewan, A, Hay, E, Davidson, C, Turnbull, Y, Erickson, J C, Marini, P, Wilson, D, McIntosh, A M, Adams, M J, Murgatroyd, C, Barrett, P, Delibegovic, M, Clarke, T-K & MacKenzie, A 2019, 'CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake', bioRxiv. https://doi.org/10.1101/572065en
dc.identifier.doi10.1101/572065
dc.identifier.otherORCID: /0000-0003-3604-2950/work/78069883
dc.identifier.otherORCID: /0000-0001-6193-3152/work/160847572
dc.identifier.otherORCID: /0000-0002-8456-4473/work/177758636
dc.identifier.urihttps://hdl.handle.net/2164/15816
dc.language.isoeng
dc.relation.ispartofbioRxiven
dc.subjectUK Biobanken
dc.subjectCRISPR genome editingen
dc.subjecttissue-specific enhanceren
dc.subjectgalaninen
dc.subjectethanol intakeen
dc.subjectanxietyen
dc.subjectPKCen
dc.subjectEGR1en
dc.subjectR Medicineen
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectBB/N017544/1en
dc.subjectRural and Environmental Science and Analytical Services (RESAS)en
dc.subjectWellcome Trusten
dc.subject104036/Z/14/Zen
dc.subjectMedical Research Council (MRC)en
dc.subjectPhD-719-2013en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleCRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intakeen
dc.typeJournal articleen

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