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The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of Aspergillus fumigatus

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dc.contributor.authordu Pré, Saskia
dc.contributor.authorBeckmann, Nicola
dc.contributor.authorAlmeida, Mariana Cruz
dc.contributor.authorSibley, Graham E M
dc.contributor.authorLaw, Derek
dc.contributor.authorBrand, Alexandra C
dc.contributor.authorBirch, Mike
dc.contributor.authorRead, Nick D
dc.contributor.authorOliver, Jason D
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.MRC Centre for Medical Mycologyen
dc.date.accessioned2019-02-01T00:05:23Z
dc.date.available2019-02-01T00:05:23Z
dc.date.embargoedUntil2019-02-01
dc.date.issued2018-08-01
dc.descriptionWe thank our colleagues at F2G Ltd. for their support in this work, as well as the Manchester Fungal Infection Group at the University of Manchester. We also thank Gillian Milne and the Microscopy and Histology Core Facility at the Medical Research Council Centre for Medical Mycology at the University of Aberdeen for their assistance with TEM. We also thank John Rex for critical reading of the manuscript. The Microscopy and Histology Core Facility at the Medical Research Council Centre for Medical Mycology at the University of Aberdeen is supported by grant number MR/N006364/1. S.D.P. and M.C.A. are supported by the European Marie Curie ITN FungiBrain grant PITN-GA-2013-607963. S.D.P. was the primary author and performed the live-cell imaging microscopy, TEM, viability staining, and the analysis of the data. N.B. performed the postexposure effect assays. M.C.A. assisted with TEM. G.E.M.S. designed F901318. N.B., A.C.B., D.L., M.B., N.D.R., and J.D.O. provided guidance and assistance during this project and in the preparation of the manuscript.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent1638520
dc.identifier125639292
dc.identifier4a447df4-55dd-4d94-a3ff-53e72d964f95
dc.identifier29891595
dc.identifier85052015245
dc.identifier.citationdu Pré, S, Beckmann, N, Almeida, M C, Sibley, G E M, Law, D, Brand, A C, Birch, M, Read, N D & Oliver, J D 2018, 'The effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of Aspergillus fumigatus', Antimicrobial Agents and Chemotherapy, vol. 62, no. 8, e00231-18, pp. 1-11. https://doi.org/10.1128/AAC.00231-18en
dc.identifier.doi10.1128/AAC.00231-18
dc.identifier.iss8en
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/2164/11851
dc.identifier.vol62en
dc.language.isoeng
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen
dc.subjectAspergillus fumigatusen
dc.subjectF901318en
dc.subjectantifungal agentsen
dc.subjectaspergillosisen
dc.subjectfilamentous fungien
dc.subjectolorofimen
dc.subjectorotomideen
dc.subjectQR Microbiologyen
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/1en
dc.subjectEuropean Commissionen
dc.subjectPITN-GA-2013-607963en
dc.subject.lccQRen
dc.subject.lccRen
dc.titleThe effect of the novel antifungal drug F901318 (Olorofim) on the growth and viability of Aspergillus fumigatusen
dc.typeJournal articleen

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