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Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement : findings from a study of 37,843 people in UK Biobank.

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dc.contributor.authorBeynon, Rhona
dc.contributor.authorSaunders, Fiona
dc.contributor.authorEbsim, Raja
dc.contributor.authorFrysz, Monika
dc.contributor.authorFaber, Ben
dc.contributor.authorGregory, Jenny
dc.contributor.authorLindner, Claudia
dc.contributor.authorSarmanova, Aliya
dc.contributor.authorAspden, Richard Malcolm
dc.contributor.authorHarvey, Nicholas C
dc.contributor.authorCootes, Timothy
dc.contributor.authorTobias, Jon H.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH)en
dc.contributor.institutionUniversity of Aberdeen.Medical Educationen
dc.contributor.institutionUniversity of Aberdeen.MRC/Versus Arthritis Centre for Musculoskeletal Health and Worken
dc.contributor.institutionUniversity of Aberdeen.Institute of Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2024-04-16T23:18:02Z
dc.date.available2024-04-16T23:18:02Z
dc.date.issued2024-06-01
dc.descriptionAcknowledgements The authors would like to express their gratitude to Dr. David Wilson, Consultant Interventional Musculoskeletal Radiologist and honorary Clinical Lecturer at The University of Aberdeen, for his valuable contribution to the development of the DXA-based osteophyte Atlas. They also extend their appreciation to all the participants of the UK Biobank study. unding This research was funded in whole, or in part, by the Wellcome Trust [Grant numbers: 209233/Z/17/Z, 223267/Z/21/Z]. BGF is funded by an NIHR Academic Clinical Lectureship. CL was funded by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). NCH is supported by grants from Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001] and the NIHR Southampton Biomedical Research Centre. AS was affiliated with the Bristol University at the time of the study conduct and is currently affiliated with Roche Diagnostics International, Clinical Development and Medical Affair. At the time this work was conducted MF was an employee at the University of Bristol. MF is now employed by Boehringer Ingelheim UK & Ireland.en
dc.description.statusPeer revieweden
dc.format.extent10
dc.format.extent1288835
dc.identifier288668258
dc.identifierd7013222-0a6f-42ab-93a8-c2155988c88e
dc.identifier85190304374
dc.identifier85190304374
dc.identifier38655015
dc.identifier.citationBeynon, R, Saunders, F, Ebsim, R, Frysz, M, Faber, B, Gregory, J, Lindner, C, Sarmanova, A, Aspden, R M, Harvey, N C, Cootes, T & Tobias, J H 2024, 'Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement : findings from a study of 37,843 people in UK Biobank.', Osteoarthritis and Cartilage Open, vol. 6, no. 2, 100468. https://doi.org/10.1016/j.ocarto.2024.100468en
dc.identifier.doi10.1016/j.ocarto.2024.100468
dc.identifier.issn2665-9131
dc.identifier.otherORCID: /0000-0001-7130-6777/work/158209198
dc.identifier.urihttps://hdl.handle.net/2164/23268
dc.language.isoeng
dc.relation.ispartofOsteoarthritis and Cartilage Openen
dc.subjectKnee shapeen
dc.subjectOsteoarthritisen
dc.subjectStatistical shape modellingen
dc.subjectOsteophytesen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subject209233/Z/17/Zen
dc.subject223267/Z/21/Zen
dc.subject223267/Z/21/Z)en
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_PC_21003en
dc.subjectMC_PC_21001en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleDual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement : findings from a study of 37,843 people in UK Biobank.en
dc.typeJournal articleen

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