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Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

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dc.contributor.authorThen, Chee Kin
dc.contributor.authorPaillas, Salome
dc.contributor.authorMoomin, Aliu
dc.contributor.authorMisheva, Mariya D.
dc.contributor.authorMoir, Rachel A.
dc.contributor.authorHay, Susan M.
dc.contributor.authorBremner, David
dc.contributor.authorRoberts (nee Nellany), Kristine S.
dc.contributor.authorSmith, Ellen E.
dc.contributor.authorHeidari, Zeynab
dc.contributor.authorSescu, Daniel
dc.contributor.authorWang, Xuedan
dc.contributor.authorSuárez-Bonnet, Alejandro
dc.contributor.authorHay, Nadine
dc.contributor.authorMurdoch, Sarah L.
dc.contributor.authorSaito, Ryoichi
dc.contributor.authorCollie-Duguid, Elaina S. R.
dc.contributor.authorRichardson, Shirley
dc.contributor.authorPriestnall, Simon L.
dc.contributor.authorWilson, Joan M.
dc.contributor.authorGurumurthy, Mahalakshmi
dc.contributor.authorRoyle, Justine S.
dc.contributor.authorSamuel, Leslie M.
dc.contributor.authorRamsay, George
dc.contributor.authorVallis, Katherine A.
dc.contributor.authorFoster, Kevin R.
dc.contributor.authorMcCullagh, James S. O.
dc.contributor.authorKiltie, Anne E.
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Biological Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Centre for Genome-Enabled Biology and Medicineen
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Medicine, Medical Sciences & Nutritionen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Centre for Evaluationen
dc.contributor.institutionUniversity of Aberdeen.Administation Applied Medicineen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cancer Centreen
dc.date.accessioned2024-05-14T10:21:01Z
dc.date.available2024-05-14T10:21:01Z
dc.date.issued2024-05-14
dc.descriptionAcknowledgements We thank Professor William Kim (University of North Carolina, Chapel Hill) for his generous gift of the UPPL1591 cell line. We thank Dr. Mark Hill (Department of Oncology, University of Oxford) for assistance with irradiation procedures, and Dr. Jia-Yu Ke and Dr. Vijay Indukuri (Research Diets, Inc.) for formulation of the mouse diets. We thank Dr. Graham Horgan (James Hutton Research Institute, Aberdeen) for statistical advice. We thank Grampian Biorepository at Aberdeen Royal Infirmary for providing the faecal samples from cancer patients.en
dc.description.statusPeer revieweden
dc.format.extent22
dc.format.extent5422759
dc.identifier288597708
dc.identifier8c359e9a-1f9d-4965-a09b-f6cf88d413cb
dc.identifier38745230
dc.identifier85193207299
dc.identifier.citationThen, C K, Paillas, S, Moomin, A, Misheva, M D, Moir, R A, Hay, S M, Bremner, D, Roberts (nee Nellany), K S, Smith, E E, Heidari, Z, Sescu, D, Wang, X, Suárez-Bonnet, A, Hay, N, Murdoch, S L, Saito, R, Collie-Duguid, E S R, Richardson, S, Priestnall, S L, Wilson, J M, Gurumurthy, M, Royle, J S, Samuel, L M, Ramsay, G, Vallis, K A, Foster, K R, McCullagh, J S O & Kiltie, A E 2024, 'Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity', Microbiome, vol. 12, no. 1, 89. https://doi.org/10.1186/s40168-024-01804-1en
dc.identifier.doi10.1186/s40168-024-01804-1
dc.identifier.iss1en
dc.identifier.issn2049-2618
dc.identifier.otherRIS: urn:9FFBBFA1C0C81D3907F3833C90AA7F80
dc.identifier.otherORCID: /0000-0002-8402-8670/work/159955479
dc.identifier.otherORCID: /0000-0001-7208-2912/work/159955696
dc.identifier.otherORCID: /0000-0003-3559-0584/work/159956091
dc.identifier.otherORCID: /0000-0002-7511-4139/work/164095108
dc.identifier.urihttps://hdl.handle.net/2164/23455
dc.identifier.vol12en
dc.language.isoeng
dc.relation.ispartofMicrobiomeen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectRadiotherapyen
dc.subjectDietary fibreen
dc.subjectGut microbiotaen
dc.subjectShort-chain fatty acidsen
dc.subjectIsoferulic aciden
dc.subjectCanceren
dc.subjectimmunomodulationen
dc.subjectR Medicineen
dc.subjectWellcome Trusten
dc.subjectRG13793-55en
dc.subjectCancer Research UKen
dc.subjectC5255/A23279en
dc.subjectA31475en
dc.subjectOtheren
dc.subjectSF10237-53en
dc.subjectSupplementary Informationen
dc.subject.lccRen
dc.titleDietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicityen
dc.typeJournal articleen

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