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Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

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dc.contributor.authorSchaefer, Katja
dc.contributor.authorWagener, Jeanette
dc.contributor.authorAmes, Ryan M
dc.contributor.authorChristou, Stella
dc.contributor.authorMacCallum, Donna M
dc.contributor.authorBates, Steven
dc.contributor.authorGow, Neil A R
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.contributor.institutionUniversity of Aberdeen.Farr Aberdeenen
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2020-08-31T11:20:01Z
dc.date.available2020-08-31T11:20:01Z
dc.date.issued2020-08-11
dc.descriptionWe thank Jane Usher (University of Exeter) for constructive criticism of the manuscript. We thank Valmik K. Vyas and Gerald R. Fink from the Whitehead Institute for Biomedical Research, Cambridge, United Kingdom, for providing the Candida CRISPR plasmid (CaCas9 Solo system pV1200 vector). N.A.R.G. acknowledges support provided by Wellcome as a Senior Investigator Award (101873/Z/13/Z), Collaborative Award (200208/A/15/Z), and Strategic Award (097377/Z11/Z) and by the MRC Centre for Medical Mycology (MR/N006364/2). R.M.A. acknowledges support from an EPSRC/BBSRC Interface Innovation Fellowship (EP/S001352/1). K.S., N.A.R.G., S.B., and J.W. conceived the study. N.A.R.G. was awarded the grant that served as a resource for this study. K.S., S.C., D.M.M., and S.B. performed experiments. K.S., N.A.R.G., S.B., and R.M.A. analyzed and interpreted results. K.S., N.A.R.G., and S.B. wrote the paper, and all of us provided comments.en
dc.description.statusPeer revieweden
dc.format.extent15
dc.format.extent2296926
dc.identifier174946982
dc.identifierd34bf47d-3483-46a0-86ba-d6148afe12f5
dc.identifier32788384
dc.identifier85089568773
dc.identifier000572064700010
dc.identifier.citationSchaefer, K, Wagener, J, Ames, R M, Christou, S, MacCallum, D M, Bates, S & Gow, N A R 2020, 'Three Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence', mBio, vol. 11, no. 4, e01845-20. https://doi.org/10.1128/mBio.01845-20en
dc.identifier.doi10.1128/mBio.01845-20
dc.identifier.iss4en
dc.identifier.issn2161-2129
dc.identifier.otherPubMedCentral: PMC7439472
dc.identifier.otherORCID: /0000-0002-7227-4348/work/79765299
dc.identifier.otherORCID: /0000-0003-4833-0378/work/79765339
dc.identifier.urihttps://hdl.handle.net/2164/15040
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85089568773&partnerID=8YFLogxKen
dc.identifier.vol11en
dc.language.isoeng
dc.relation.ispartofmBioen
dc.subjectcandidaen
dc.subjectarginaseen
dc.subjectguanidinobutyraseen
dc.subjectagmatinaseen
dc.subjectimmunityen
dc.subjectmorphogenesisen
dc.subjectcandida albicansen
dc.subjectmacrophagesen
dc.subjectCandida albicansen
dc.subjectArginaseen
dc.subjectAgmatinaseen
dc.subjectMacrophagesen
dc.subjectImmunityen
dc.subjectMorphogenesisen
dc.subjectGuanidinobutyraseen
dc.subjectCandidaen
dc.subjectDECARBOXYLASEen
dc.subjectPUTRESCINE BIOSYNTHETIC ENZYMEen
dc.subjectNITRIC-OXIDEen
dc.subjectPOLYAMINE BIOSYNTHESISen
dc.subjectDEIMINASEen
dc.subjectASPERGILLUS-NIGERen
dc.subjectMECHANISMSen
dc.subjectIDENTIFICATIONen
dc.subjectGENEen
dc.subjectUREOHYDROLASEen
dc.subjectQR Microbiologyen
dc.subjectR Medicineen
dc.subjectVirologyen
dc.subjectMicrobiologyen
dc.subjectEngineering and Physical Sciences Research Council (EPSRC)en
dc.subjectEP/S001352/1en
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N006364/2en
dc.subjectWellcome Trusten
dc.subject101873/Z/13/Zen
dc.subject200208/A/15/Zen
dc.subject097377/Z11/Zen
dc.subjectSupplementary Dataen
dc.subject.lccQRen
dc.subject.lccRen
dc.titleThree Related Enzymes in Candida albicans Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulenceen
dc.typeJournal articleen

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