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An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression

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dc.contributor.authorCano-Gamez, Eddie
dc.contributor.authorBurnham, Katie L.
dc.contributor.authorGoh, Cyndi
dc.contributor.authorAllcock, Alice
dc.contributor.authorMalick, Zunaira H.
dc.contributor.authorOverend, Lauren
dc.contributor.authorKwok, Andrew
dc.contributor.authorSmith, David A.
dc.contributor.authorPeters-Sengers, Hessel
dc.contributor.authorAntclife, David
dc.contributor.authorMcKechnie, Stuart
dc.contributor.authorScicluna, Brendon P.
dc.contributor.authorvan der Poll, Tom
dc.contributor.authorGordon, Anthony C.
dc.contributor.authorHinds, Charles J.
dc.contributor.authorDavenport, Emma E.
dc.contributor.authorKnight, Julian C.
dc.contributor.authorWebster, Nigel
dc.contributor.authorGalley, Helen
dc.contributor.authorTaylor, Jane
dc.contributor.authorHall, Sally
dc.contributor.authorAddison, Jenni
dc.contributor.authorRoughton, Sian
dc.contributor.authorTennant, Heather
dc.contributor.authorGuleri, Achyut
dc.contributor.authorWaddington, Natalia
dc.contributor.authorArawwawala, Dilshan
dc.contributor.authorDurcan, John
dc.contributor.authorShort, Alasdair
dc.contributor.authorSwan, Karen
dc.contributor.authorWilliams, Sarah
dc.contributor.authorSmolen, Susan
dc.contributor.authorMitchell-Inwang, Christine
dc.contributor.authorGordon, Tony
dc.contributor.authorErrington, Emily
dc.contributor.authorTempleton, Maie
dc.contributor.authorVenatesh, Pyda
dc.contributor.authorWard, Geraldine
dc.contributor.authorMcCauley, Marie
dc.contributor.authorBaudouin, Simon
dc.contributor.authorHigham, Charley
dc.contributor.authorSoar, Jasmeet
dc.contributor.authorGrier, Sally
dc.contributor.authorHall, Elaine
dc.contributor.authorBrett, Stephen
dc.contributor.authorKitson, David
dc.contributor.authorWilson, Robert
dc.contributor.authorMountford, Laura
dc.contributor.authorMoreno, Juan
dc.contributor.authorHall, Peter
dc.contributor.authorGAinS Investigators
dc.contributor.institutionUniversity of Aberdeen.Applied Medicineen
dc.date.accessioned2023-07-24T09:02:01Z
dc.date.available2023-07-24T09:02:01Z
dc.date.issued2022-11-02
dc.descriptionFunding Information: This work was funded in whole, or in part, by the Medical Research Council (MR/V002503/1) (J.C.K. and E.E.D.); Wellcome Trust Investigator Award (204969/Z/16/Z) (J.C.K.); Wellcome Trust core funding to the Wellcome Sanger Institute (grant numbers 206194 and 108413/A/15/D); Wellcome Trust grants (090532/Z/09/Z and 203141/Z/16/Z) to core facilities; Wellcome Centre for Human Genetics; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant number: 2018-I2M-2-002); and National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (J.C.K.). A.C.G. is supported by an NIHR Research Professor award (RP-2015-06-018) and the NIHR Imperial Biomedical Research Center. We thank all the patients, patient families, nurses, and clinicians who participated in the GAinS and MARS studies; and the COMBAT Consortium, MOSAIC Consortium, and DeCOI.en
dc.description.statusPeer revieweden
dc.format.extent36
dc.format.extent3674568
dc.identifier265399620
dc.identifier21fbe35b-a3d4-4d54-a0fc-134539092ff1
dc.identifier85142089291
dc.identifier36322631
dc.identifier.citationCano-Gamez, E, Burnham, K L, Goh, C, Allcock, A, Malick, Z H, Overend, L, Kwok, A, Smith, D A, Peters-Sengers, H, Antclife, D, McKechnie, S, Scicluna, B P, van der Poll, T, Gordon, A C, Hinds, C J, Davenport, E E, Knight, J C, Webster, N, Galley, H, Taylor, J, Hall, S, Addison, J, Roughton, S, Tennant, H, Guleri, A, Waddington, N, Arawwawala, D, Durcan, J, Short, A, Swan, K, Williams, S, Smolen, S, Mitchell-Inwang, C, Gordon, T, Errington, E, Templeton, M, Venatesh, P, Ward, G, McCauley, M, Baudouin, S, Higham, C, Soar, J, Grier, S, Hall, E, Brett, S, Kitson, D, Wilson, R, Mountford, L, Moreno, J, Hall, P & GAinS Investigators 2022, 'An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression', Science translational medicine, vol. 14, no. 669, eabq4433. https://doi.org/10.1126/scitranslmed.abq4433en
dc.identifier.doi10.1126/scitranslmed.abq4433
dc.identifier.iss669en
dc.identifier.issn1946-6234
dc.identifier.urihttps://hdl.handle.net/2164/21281
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85142089291&partnerID=8YFLogxKen
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613832/en
dc.identifier.vol14en
dc.language.isoeng
dc.relation.ispartofScience translational medicineen
dc.subjectAdulten
dc.subjectHumansen
dc.subjectChilden
dc.subjectInfluenza A Virus, H1N1 Subtypeen
dc.subjectGene Expression Profilingen
dc.subjectCOVID-19en
dc.subjectSepsis/geneticsen
dc.subjectTranscriptome/geneticsen
dc.subjectR Medicineen
dc.subjectGeneral Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/V002503/1en
dc.subjectWellcome Trusten
dc.subject206194en
dc.subject108413/A/15/Den
dc.subject090532/Z/09/Zen
dc.subject203141/Z/16/Zen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectRP-2015-06-018en
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titleAn immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expressionen
dc.typeJournal articleen

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