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Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease

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dc.contributor.authorDehghan, Abbas
dc.contributor.authorPinto, Rui Climaco
dc.contributor.authorKaraman, Ibrahim
dc.contributor.authorHuang, Jian
dc.contributor.authorDurainayagam, Brenan R.
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorNazeer, Areesha
dc.contributor.authorZhong, Qi
dc.contributor.authorLiggi, Sonia
dc.contributor.authorWhiley, Luke
dc.contributor.authorMustafa, Rima
dc.contributor.authorKivipelto, Miia
dc.contributor.authorSolomon, Alina
dc.contributor.authorNgandu, Tiia
dc.contributor.authorKanekiyo, Takahisa
dc.contributor.authorAikawa, Tomonori
dc.contributor.authorRadulescu, Carola I.
dc.contributor.authorBarnes, Samuel J.
dc.contributor.authorGraça, Gonçalo
dc.contributor.authorChekmeneva, Elena
dc.contributor.authorCamuzeaux, Stephane
dc.contributor.authorLewis, Matthew R.
dc.contributor.authorKaluarachchi, Manuja R.
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorHolmes, Elaine
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorMatthews, Paul M.
dc.contributor.authorGriffin, Julian L.
dc.contributor.authorElliott, Paul
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.date.accessioned2023-07-06T15:26:01Z
dc.date.available2023-07-06T15:26:01Z
dc.date.issued2022-10-25
dc.descriptionThe authors thank Prof. Takashi Saito, Nagoya City University Graduate School of Medical Sciences, Japan and Prof. Takomi Saido, RIKEN Centre for Brain Science, Japan for access to the AppNL-G-F mouse model. The authors also want to thank Dr. Jenny Hällqvist for helping to illustrate Fig. 7. This work is supported by the UK Dementia Research Institute at Imperial College, which receives its funding from UK Dementia Research Institute Ltd., funded by the UK Medical Research Council (MRC), Alzheimer’s Society, and Alzheimer’s Research UK. A.D. is funded by a Wellcome Trust seed award (206046/Z/17/Z). R.M. is funded by the President’s PhD Scholarship from Imperial College London. P.M.M. acknowledges generous personal and research support from the Edmond J. Safra Foundation and Lily Safra and a National Institute for Health Research (NIHR) Senior Investigator Award (to 2020). J.L.G. is funded by the MRC (MC_UP_A090_1006, MC_PC_13030, MR/P011705/1, MR/P01836X/1 , and MR/S010483/1) and Wellcome Trust (MetaboFlow). M.K. is funded by the NIHR Imperial Biomedical Research Centre (BRC), Wallenberg Clinical Scholars, Academy of Finland, and Swedish Research Council. A.S. is funded by the Academy of Finland (287490, 294061, and 319318), European Research Council (804371), Alzheimerfonden, and Region Stockholm ALF (Sweden). This work was supported by the MRC and NIHR (grant No. MC_PC_12025). P.E. is the director of the MRC Centre for Environment and Health (MR/L01341X/1). He acknowledges support from the NIHR Health Protection Research Units in Chemical and Radiation Threats and Hazards and Health Impact of Environmental Hazards. P.E. is a codirector of the Health Data Research UK London site, which is supported, among others, by MRC, NIHR, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Wellcome Trust, and British Heart Foundation (BHF). P.E. acknowledges support from the BHF Centre for Research Excellence at Imperial College. Infrastructure support for this research was provided by the NIHR Imperial BRC Science.en
dc.description.statusPeer revieweden
dc.format.extent12
dc.format.extent6104710
dc.identifier221796622
dc.identifier1891e1c2-a214-4195-968b-bacbca243e55
dc.identifier85140348906
dc.identifier36269859
dc.identifier.citationDehghan, A, Pinto, R C, Karaman, I, Huang, J, Durainayagam, B R, Ghanbari, M, Nazeer, A, Zhong, Q, Liggi, S, Whiley, L, Mustafa, R, Kivipelto, M, Solomon, A, Ngandu, T, Kanekiyo, T, Aikawa, T, Radulescu, C I, Barnes, S J, Graça, G, Chekmeneva, E, Camuzeaux, S, Lewis, M R, Kaluarachchi, M R, Ikram, M A, Holmes, E, Tzoulaki, I, Matthews, P M, Griffin, J L & Elliott, P 2022, 'Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 43, e2206083119. https://doi.org/10.1073/pnas.2206083119en
dc.identifier.doi10.1073/pnas.2206083119
dc.identifier.iss43en
dc.identifier.issn0027-8424
dc.identifier.otherORCID: /0000-0003-1336-7744/work/131351858
dc.identifier.urihttps://hdl.handle.net/2164/21130
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85140348906&partnerID=8YFLogxKen
dc.identifier.vol119en
dc.language.isoeng
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen
dc.subjectABCA7en
dc.subjectAlzheimer’s diseaseen
dc.subjectceramideen
dc.subjectgenome-wide association studyen
dc.subjectmetabolomicsen
dc.subjectR Medicineen
dc.subjectGeneralen
dc.subjectMedical Research Council (MRC)en
dc.subjectMC_PC_12025en
dc.subjectMR/L01341X/1en
dc.subjectMC_UP_A090_1006en
dc.subjectMC_PC_13030en
dc.subjectMR/P011705/1en
dc.subjectMR/P01836X/1en
dc.subjectMR/S010483/1en
dc.subjectWellcome Trusten
dc.subject206046/Z/17/Zen
dc.subjectMetaboFlowen
dc.subjectNational Institute for Health Research (NIHR)en
dc.subjectSenior Investigator Awarden
dc.subjectMC_PC_12025en
dc.subjectEuropean Research Councilen
dc.subject804371en
dc.subjectBritish Heart Foundationen
dc.subject.lccRen
dc.titleMetabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's diseaseen
dc.typeJournal articleen

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