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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

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dc.contributor.authorParis, Jasmin
dc.contributor.authorMorgan, Marcos
dc.contributor.authorCampos, Joana
dc.contributor.authorSpencer, Gary J
dc.contributor.authorShmakova, Alena
dc.contributor.authorIvanova, Ivayla
dc.contributor.authorMapperley, Christopher
dc.contributor.authorLawson, Hannah
dc.contributor.authorWotherspoon, David A
dc.contributor.authorSepulveda, Catarina
dc.contributor.authorVukovic, Milica
dc.contributor.authorAllen, Lewis
dc.contributor.authorSarapuu, Annika
dc.contributor.authorTavosanis, Andrea
dc.contributor.authorGuitart, Amelie V
dc.contributor.authorVillacreces, Arnaud
dc.contributor.authorMuch, Christian
dc.contributor.authorChoe, Junho
dc.contributor.authorAzar, Ali
dc.contributor.authorvan de Lagemaat, Louie N
dc.contributor.authorVernimmen, Douglas
dc.contributor.authorNehme, Ali
dc.contributor.authorMazurier, Frederic
dc.contributor.authorSomervaille, Tim C P
dc.contributor.authorGregory, Richard I
dc.contributor.authorO'Carroll, Dónal
dc.contributor.authorKranc, Kamil R
dc.date.accessioned2024-04-16T11:00:01Z
dc.date.available2024-04-16T11:00:01Z
dc.date.issued2019-07-03
dc.descriptionK.R.K. is a Cancer Research UK (CRUK) Senior Cancer Research Fellow and a CRUK Programme Grant holder. This work is funded by CRUK (awards C29967/A14633 and C29967/A26787 to K.R.K.) and Wellcome (award 106144 to D.O.). K.R.K.’s laboratory is also supported by grants from The Barts Charity, Wellcome, Bloodwise, Medical Research Council, and the Kay Kendall Leukaemia Fund. D.O. is a member of the Wellcome Centre for Cell Biology supported by Wellcome core funding (award 092076). G.J.S. and T.C.P.S. are supported by CRUK (award C5759/A20971). Part of this work was carried out in the framework of the European Cost Action EPITRAN CA16120.en
dc.description.statusPeer revieweden
dc.format.extent19
dc.format.extent5989263
dc.identifier272592815
dc.identifier5436329c-d6cd-4026-b4ca-bf7c331a3b73
dc.identifier31031138
dc.identifier85068056394
dc.identifier.citationParis, J, Morgan, M, Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D A, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A V, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L N, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K R 2019, 'Targeting the RNA m 6 A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia', Cell stem cell, vol. 25, no. 1, pp. 137-148, e1-.e6. https://doi.org/10.1016/j.stem.2019.03.021en
dc.identifier.doi10.1016/j.stem.2019.03.021
dc.identifier.iss1en
dc.identifier.issn1875-9777
dc.identifier.otherPubMedCentral: PMC6617387
dc.identifier.otherORCID: /0000-0002-2947-1557/work/140426474
dc.identifier.urihttps://hdl.handle.net/2164/23253
dc.identifier.urlhttps://europepmc.org/articles/PMC6617387en
dc.identifier.vol25en
dc.language.isoeng
dc.relation.ispartofCell stem cellen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectAnimalsen
dc.subjectCell Self Renewalen
dc.subjectHematopoiesisen
dc.subjectHematopoietic Stem Cellsen
dc.subjectHumansen
dc.subjectLeukemia, Myeloid, Acute/geneticsen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Knockouten
dc.subjectNeoplastic Stem Cells/physiologyen
dc.subjectRNA, Small Interfering/geneticsen
dc.subjectRNA-Binding Proteins/geneticsen
dc.subjectTHP-1 Cellsen
dc.subjectR Medicineen
dc.subjectCancer Research UKen
dc.subjectC29967/A14633en
dc.subjectC29967/A26787en
dc.subjectC5759/A20971en
dc.subjectWellcome Trusten
dc.subject106144en
dc.subject092076en
dc.subject.lccRen
dc.titleTargeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemiaen
dc.typeJournal articleen

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