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Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression

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dc.contributor.authorWagner, Stefan
dc.contributor.authorBrierley, Daniel I
dc.contributor.authorLeeson-Payne, Alasdair
dc.contributor.authorJiang, Wanqing
dc.contributor.authorChianese, Raffaella
dc.contributor.authorLam, Brian Y H
dc.contributor.authorDowsett, Georgina K C
dc.contributor.authorCristiano, Claudia
dc.contributor.authorLyons, David
dc.contributor.authorReimann, Frank
dc.contributor.authorGribble, Fiona M
dc.contributor.authorMartinez de Morentin, Pablo B
dc.contributor.authorYeo, Giles S H
dc.contributor.authorTrapp, Stefan
dc.contributor.authorHeisler, Lora K
dc.contributor.institutionUniversity of Aberdeen.Rowett Instituteen
dc.contributor.institutionUniversity of Aberdeen.Aberdeen Cardiovascular and Diabetes Centreen
dc.date.accessioned2023-02-06T15:45:01Z
dc.date.available2023-02-06T15:45:01Z
dc.date.issued2023-02
dc.descriptionAcknowledgements The authors thank Dr Alasdair S. Garfield, and staff within the University of Aberdeen Medical Research Facility and the Microscopy Facility for their technical assistance. pAAV-mCherry-flex-dtA was a gift from Naoshige Uchida. Work was supported by the Biotechnology and Biological Sciences Research Council (BB/R01857X/1, BB/V016849/1 to LKH and BB/S017593/1 to BYHL), the European Foundation for the Study of Diabetes (Merck Sharpe Dohme grant to ST), the Medical Research Council (MC/PC/15077 to LKH, MR/N02589X/1 to ST and MRC_MC_UU_12012/3 to FR and FMG, and MC_UU_00014/1 to GSHY), the NIH (R01 DK095757 to ST), the Wellcome Trust (WT081713 to LKH, 106262/Z/14/Z, 106263/Z/14/Z to FR and FMG, and 223279/Z/21/Z to DIB) and the Wellcome Trust Institutional Strategic Support Fund to the University of Aberdeen (204815/Z/16/Z to LKH). Next-generation sequencing was performed by IMS Genomics and transcriptomics core facility, which is supported by the MRC (MC_UU_00014/5) and the Wellcome Trust (208363/Z/17/Z), and the Cancer Research UK Cambridge Institute Genomics Core. GKCD is funded by a BBSRC CASE 4-year PhD studentship, co-funded by Novo Nordisk. WJ is supported by a UCL ORS scholarship and a CSC scholarship from the Chinese Government.en
dc.description.statusPeer revieweden
dc.format.extent11
dc.format.extent3486629
dc.identifier225811824
dc.identifier4aa7cc78-d1e7-4238-8f32-802e40659a00
dc.identifier36592795
dc.identifier85146136947
dc.identifier.citationWagner, S, Brierley, D I, Leeson-Payne, A, Jiang, W, Chianese, R, Lam, B Y H, Dowsett, G K C, Cristiano, C, Lyons, D, Reimann, F, Gribble, F M, Martinez de Morentin, P B, Yeo, G S H, Trapp, S & Heisler, L K 2023, 'Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression', Molecular Metabolism, vol. 68, 101665. https://doi.org/10.1016/j.molmet.2022.101665en
dc.identifier.doi10.1016/j.molmet.2022.101665
dc.identifier.issn2212-8778
dc.identifier.otherORCID: /0000-0002-1823-2913/work/128322172
dc.identifier.otherORCID: /0000-0002-0684-3215/work/127118034
dc.identifier.urihttps://hdl.handle.net/2164/19993
dc.identifier.vol68en
dc.language.isoeng
dc.relation.ispartofMolecular Metabolismen
dc.subjectSDG 3 - Good Health and Well-beingen
dc.subjectLorcaserinen
dc.subjectLiraglutideen
dc.subjectPreproglucagonen
dc.subjectNucleus tractus solitariien
dc.subjectBrainstemen
dc.subjectSerotonin 2C receptoren
dc.subjectR Medicineen
dc.subjectMedical Research Council (MRC)en
dc.subjectMR/N02589X/1en
dc.subjectMC/PC/15077en
dc.subjectMRC_MC_UU_12012/3en
dc.subjectBiotechnology and Biological Sciences Research Council (BBSRC)en
dc.subjectB/R01857X/1en
dc.subjectBB/V016849/1en
dc.subjectBB/S017593/1en
dc.subjectWellcome Trusten
dc.subjectWT081713en
dc.subject106262/Z/14/Zen
dc.subject106263/Z/14/Zen
dc.subject223279/Z/21/Zen
dc.subject208363/Z/17/Zen
dc.subject.lccRen
dc.titleObesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppressionen
dc.typeJournal articleen

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