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Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

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dc.contributor.authorKiel, Christina
dc.contributor.authorStrunz, Tobias
dc.contributor.authorInternational AMD Genomics Consortium (IAMDGC)
dc.contributor.authorGrassmann, Felix
dc.contributor.authorWeber, Bernhard H.F.
dc.contributor.institutionUniversity of Aberdeen.Medical Sciencesen
dc.date.accessioned2020-11-11T15:07:01Z
dc.date.available2020-11-11T15:07:01Z
dc.date.issued2020-10-08
dc.descriptionFunding This research was funded by the Deutsche Forschungsgemeinschaft (GR5065/1-1) and institutional funds (Titel 77). Acknowledgments All contributing sites and additional funding information for the IAMDGC data are acknowledged in this publication: Fritsche et al. (2016) Nature Genetics 48 134–143, (doi:10.1038/ng.3448); The International AMD Genomics consortium’s web page is: http://eaglep.case.edu/iamdgc_web/, and additional information is available on: http://csg.sph.umich.edu/abecasis/public/amd2015/. GERA data came from a grant, the Resource for Genetic Epidemiology Research in Adult Health and Aging (RC2 AG033067; Schaefer and Risch, PIs) awarded to the Kaiser Permanente Research Program on Genes, Environment, and Health (RPGEH) and the UCSF Institute for Human Genetics. The RPGEH was supported by grants from the Robert Wood Johnson Foundation, the Wayne and Gladys Valley Foundation, the Ellison Medical Foundation, Kaiser Permanente Northern California, and the Kaiser Permanente National and Northern California Community Benefit Programs. The RPGEH and the Resource for Genetic Epidemiology Research in Adult Health and Aging are described in the following publication, Schaefer C, et al., The Kaiser Permanente Research Program on Genes, Environment and Health: Development of a Research Resource in a Multi-Ethnic Health Plan with Electronic Medical Records, In preparation, 2013. This research has been conducted using the UK Biobank Resource under Application Number 44862. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health (commonfund.nih.gov/GTEx). Additional funds were provided by the NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. Donors were enrolled at Biospecimen Source Sites funded by NCI\Leidos Biomedical Research, Inc. subcontracts to the National Disease Research Interchange (10XS170), Roswell Park Cancer Institute (10XS171), and Science Care, Inc. (X10S172). The Laboratory, Data Analysis, and Coordinating Center (LDACC) was funded through a contract (HHSN268201000029C) to The Broad Institute, Inc. Biorepository operations were funded through a Leidos Biomedical Research, Inc. subcontract to Van Andel Research Institute (10ST1035). Additional data repository and project management were provided by Leidos Biomedical Research, Inc. (HHSN261200800001E). The Brain Bank was supported supplements to University of Miami grant DA006227. Statistical Methods development grants were made to the University of Geneva (MH090941 & MH101814), the University of Chicago (MH090951, MH090937, MH101825, & MH101820), the University of North Carolina—Chapel Hill (MH090936), North Carolina State University (MH101819), Harvard University (MH090948), Stanford University (MH101782), Washington University (MH101810), and to the University of Pennsylvania (MH101822). The datasets used for the analyses described in this manuscript were obtained from dbGaP at http://www.ncbi.nlm.nih.gov/gap through dbGaP accession number phs000424.v8.p2.en
dc.description.statusPeer revieweden
dc.format.extent18
dc.format.extent3117646
dc.identifier179469856
dc.identifierad9ab4ab-4e9f-4f46-a7fa-26ba27a1b864
dc.identifier85092886172
dc.identifier33050031
dc.identifier.citationKiel, C, Strunz, T, International AMD Genomics Consortium (IAMDGC), Grassmann, F & Weber, B H F 2020, 'Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)', Cells, vol. 9, no. 10, 2257. https://doi.org/10.3390/cells9102257en
dc.identifier.doi10.3390/cells9102257
dc.identifier.iss10en
dc.identifier.issn2073-4409
dc.identifier.otherORCID: 0000-0003-1390-7528
dc.identifier.otherORCID: 0000-0003-3154-4847
dc.identifier.otherORCID: 0000-0002-3744-9595
dc.identifier.otherORCID: 0000-0002-8808-7723
dc.identifier.otherORCID: /0000-0003-1390-7528/work/83311216
dc.identifier.urihttps://hdl.handle.net/2164/15353
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85092886172&partnerID=8YFLogxKen
dc.identifier.vol9en
dc.language.isoeng
dc.relation.ispartofCellsen
dc.subjectage-related macular degenerationen
dc.subjectchoroidal neovascularizationen
dc.subjecteQTLen
dc.subjectgender specificityen
dc.subjectlocus analysisen
dc.subjectmiRNA varianten
dc.subjectpleiotropyen
dc.subjectR Medicineen
dc.subjectGeneral Medicineen
dc.subjectSupplementary Dataen
dc.subject.lccRen
dc.titlePleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)en
dc.typeJournal articleen

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