Machine-learning derived acetabular dysplasia and cam morphology are features of severe hip osteoarthritis : findings from UK Biobank

Frysz, MonikaFaber, Benjamin GEbsim, RajaSaunders, FionaLindner, ClaudiaGregory, JennyAspden, Richard MalcolmHarvey, Nicholas CCootes, TimothyTobias, Jonathan H.2022-09-152022-09-152022-09-01Frysz, M, Faber, B G, Ebsim, R, Saunders, F, Lindner, C, Gregory, J, Aspden, R M, Harvey, N C, Cootes, T & Tobias, J H 2022, 'Machine-learning derived acetabular dysplasia and cam morphology are features of severe hip osteoarthritis : findings from UK Biobank', Journal of Bone and Mineral Research, vol. 37, no. 9, pp. 1720-1732. https://doi.org/10.1002/jbmr.46490884-0431ORCID: /0000-0001-7130-6777/work/116418066https://hdl.handle.net/2164/19175Acknowledgements and disclosures The authors would like to thank Dr Martin Williams, Consultant Musculoskeletal Radiologist North Bristol NHS Trust, who provided substantial training and expertise in osteophyte assessment on DXA images. This research has been conducted using the UK Biobank Resource (application number 17295). Financial Support: RE, MF, FS are supported, and this work is funded by a Wellcome Trust collaborative award (reference number 209233). BGF is supported by a Medical Research Council (MRC) clinical research training fellowship (MR/S021280/1). CL was funded by the MRC, UK (MR/S00405X/1) as well as a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (223267/Z/21/Z). NCH acknowledges support from the MRC and NIHR Southampton Biomedical Research Centre, University of Southampton, and University Hospital Southampton. This research was funded in whole, or in part, by the Wellcome Trust [Grant number 223267/Z/21/Z]. NCH has received consultancy, lecture fees and honoraria from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, UCB, Shire, Consilient Healthcare, Kyowa Kirin and Internis Pharma. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.132416936engosteoarthritiship shapestatistical shape modellingcam morphologyacetabular dysplasiaR MedicineWellcome Trust223267/Z/21/Z209233Medical Research Council (MRC)MR/S021280/1MR/S00405X/1RMachine-learning derived acetabular dysplasia and cam morphology are features of severe hip osteoarthritis : findings from UK BiobankJournal article10.1002/jbmr.4649379