Al-Hilaly, Youssra K.Pollack, Saskia J.Rickard, Janet E.Simpson, MichaelRaulin, Ana-CBaddeley, ThomasSchellenberger, PascaleStorey, John M. D.Harrington, Charles R.Wischik, Claude M.Serpell, Louise C.2018-10-122018-10-122018-10-19Al-Hilaly, Y K, Pollack, S J, Rickard, J E, Simpson, M, Raulin, A-C, Baddeley, T, Schellenberger, P, Storey, J M D, Harrington, C R, Wischik, C M & Serpell, L C 2018, 'Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)', Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131. https://doi.org/10.1016/j.jmb.2018.08.0100022-2836ORCID: /0000-0002-5261-5467/work/73579165ORCID: /0000-0003-2250-3920/work/173415892http://hdl.handle.net/2164/11249TEM work was performed at the School of Life Sciences TEM Imaging Centre at the University of Sussex, which is supported by the Wellcome Trust and RM Phillips. SP and AR are supported by a Sussex Neuroscience doctoral training centre. LCS is supported by Alzheimer's Society and Alzheimer's Research UK Southcoast Network. YA, JR, TB and MS are supported by TauRx Therapeutics Ltd. and CH, JS and CW serve as officers in TauRx Therapeutics Ltd.132396281engTauMethylthioniniumHydromethylthionineNeurofibrillary tanglesCircular dichroismElectron microscopyRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryQD ChemistryAlzheimers Research UKRC0321QDJournal article10.1016/j.jmb.2018.08.01043021