Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1

Garzón, JavierRodríguez, RubénKong, ZiqingChabes, AndreiRodríguez-Acebes, SaraMéndez, JuanMoreno, SergioGarcía-Higuera, Irene2017-12-132017-12-132017-10-19Garzón, J, Rodríguez, R, Kong, Z, Chabes, A, Rodríguez-Acebes, S, Méndez, J, Moreno, S & García-Higuera, I 2017, 'Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1', Oncogene, vol. 63, no. 42, pp. 5808-5818. https://doi.org/10.1038/onc.2017.1860950-9232ORCID: /0000-0002-5093-8385/work/46964300http://hdl.handle.net/2164/9773This research was funded by grants from the Spanish Ministry of Economy and Competitiveness MINECO (CSD2007-0015, BFU2011-28274 and BFU2014-55439) and Junta de Castilla y León (CSI151U13 and CSI084U16), the Swedish Cancer Society, the Knut and Alice Wallenberg Foundation and the Swedish Research Council (A.C.). I.G.H is supported by Fundación Científica de la Asociación Española contra el Cáncer (AECC). J.G. and R.R were recipients of CSIC JAE and FPU predoctoral fellowships (MINECO)1112572942engAPC/CCdh1RRM2dNTPsR Medicine (General)R1Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1Journal article10.1038/onc.2017.1866342