O'Shaughnessy, Peter J.Antignac, Jean-PhilippeLe Bizec, BrunoMorvan, Marie-LineSvechnikov, KonstantinSöder, OlleSavchuk, IuliiaMonteiro, AnaSoffientini, UgoJohnston, Zoe C.Bellingham, MichelleHough, DeniseWalker, NatashaFilis, PanagiotisFowler , Paul A.2019-02-212019-02-212019-02-14O'Shaughnessy, P J, Antignac, J-P, Le Bizec, B, Morvan, M-L, Svechnikov, K, Söder, O, Savchuk, I, Monteiro, A, Soffientini, U, Johnston, Z C, Bellingham, M, Hough, D, Walker, N, Filis, P & Fowler , P A 2019, 'Alternative (backdoor) androgen production and masculinization in the human fetus', PLoS Biology, vol. 17, no. 2, e3000002. https://doi.org/10.1371/journal.pbio.3000002, https://doi.org/10.1371/journal.pbio.3000002.s004, https://doi.org/10.1371/journal.pbio.3000002.s001, https://doi.org/10.1371/journal.pbio.3000002.s002, https://doi.org/10.1371/journal.pbio.3000002.s003, https://doi.org/10.1371/journal.pbio.3000002.s005, https://doi.org/10.1371/journal.pbio.3000002.s006, https://doi.org/10.1371/journal.pbio.3000002.s007, https://doi.org/10.1371/journal.pbio.3000002.s008, https://doi.org/10.1371/journal.pbio.3000002.s0091544-9173ORCID: /0000-0002-4831-9075/work/56076470Mendeley: 9b37ef82-c5eb-3fa0-954a-9f3038f578b8http://hdl.handle.net/2164/11944Funding: The study was supported by the following grants: Chief Scientist Office (Scottish Executive, CZG/4/742) (PAF and PJOS) (http://www.cso.scot.nhs.uk/funding-2/); NHS Grampian Endowments 08/02 (PAF and PJOS) and 15/1/010 (PAF, PF, US, and PJOS) (https://www.nhsgcharities.com/); the Glasgow Children’s Hospital Research Charity Research Fund, YRSS/PHD/2016/05 (NW, MB, PJOS, and PAF) (http://www.glasgowchildrenshospitalcharity.org/research/glasgow-childrens-hospital-charity-research-fund); the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement number 212885 (PAF) (https://ec.europa.eu/research/fp7/index_en.cfm); Medical Research Council Grants MR/L010011/1 (PAF and PJOS) and MR/K501335/1 (MB, PAF, and PJOS) (https://mrc.ukri.org/); and the Kronprinsessan Lovisas Foundation, “Stiftelsen Gunvor och Josef Anérs,” the “Stiftelsen Jane och Dan Olssons,” and the “Stiftelsen Tornspiran” (KS and OS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.233294209engSDG 3 - Good Health and Well-beingandrogenalternative pathwayandrosteronemasculinisationhumanfetaltestisplacentaadrenalliverbackdoor pathwayFETAL PLASMAWALLABY POUCH YOUNG17,20-LYASE ACTIVITYENZYME EXPRESSIONMASS-SPECTROMETRYPLASMA TESTOSTERONEP450 OXIDOREDUCTASEBIOSYNTHESISGENE-EXPRESSIONMATERNAL SMOKINGR MedicineGeneral Agricultural and Biological SciencesGeneral Biochemistry,Genetics and Molecular BiologyGeneral Immunology and MicrobiologyGeneral NeuroscienceMedical Research Council (MRC)MR/L010011/1MR/K501335/1Supplementary DataRJournal article10.1371/journal.pbio.3000002http://www.scopus.com/inward/record.url?scp=85061570315&partnerID=8YFLogxKhttp://www.mendeley.com/research/alternative-backdoor-androgen-production-masculinization-human-fetus172