Hultcrantz, MonicaRind, DavidAkl, Elie A.Treweek, ShaunMustafa, Reem AIorio, AlfonsoAlper, Brian SMeerpohl, Joerg JMurad, M HassanAnsari, Mohammed TKatikireddi, Srinivasa VittalÖstlund, PernillaTranæus, SofiaChristensen, RobinGartlehner, GeraldBrozek, JanIzcovich, ArielSchünemann, HolgerGuyatt, Gordon2017-06-272017-06-272017-07Hultcrantz, M, Rind, D, Akl, E A, Treweek, S, Mustafa, R A, Iorio, A, Alper, B S, Meerpohl, J J, Murad, M H, Ansari, M T, Katikireddi, S V, Östlund, P, Tranæus, S, Christensen, R, Gartlehner, G, Brozek, J, Izcovich, A, Schünemann, H & Guyatt, G 2017, 'The GRADE Working Group clarifies the construct of certainty of evidence', Journal of Clinical Epidemiology, vol. 87, pp. 4-13. https://doi.org/10.1016/j.jclinepi.2017.05.0060895-4356ORCID: /0000-0002-7239-7241/work/186968411http://hdl.handle.net/2164/8878The authors would like to thank colleagues at the Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU) who, through participating in a series of seminars, contributed with valuable input on the initial draft of the presented approaches. The authors also thank all GRADE Working Group members who have contributed to the paper during group discussions at Grade Working Group meetings. The Health Services Research Unit, University of Aberdeen, receives core funding from the Chief Scientist Office of the Scottish Government Health Directorates. The Parker Institute, Bispebjerg and Frederiksberg Hospital is supported by a core grant from the Oak Foundation (OCAY-13-309). SVK is funded by a NRS Scottish Senior Clinical Fellowship (SCAF/15/02), the Medical Research Council (MC_UU_12017/13 & MC_UU_12017/15) and Chief Scientist’s Office (SPHSU13 & SPHSU15).10340015engGRADEcertainty of evidencethresholdsguidelinessystematic reviewshealth technology assessmentR MedicineGeneral MedicineMedical Research Council (MRC)MC_UU_12017/13MC_UU_12017/15Chief Scientist Office (CSO)SPHSU13SPHSU15RJournal article10.1016/j.jclinepi.2017.05.00687