Lee, Tae YoonPrice, DavidYadav, Chandra PrakashRoy, RupsaHuey Mien, Laura LimWang, EileenWechsler, Michael EJackson, David JBusby, JohnHeaney, Liam GPfeffer, Paul EMahboub, BassamPerng, Diahn WarngCosio, Borja G.Perez de Llano, LuisAl-Lehebi, RiyadLarenas-Linnemann, DésiréeAl-Ahmad, MonaRhee, Chin KookIwanaga, TakashiHeffler, EnricoCanonica, Giorgio WalterCostello, Richard WPapadopoulos, Nikolaos GPapaioannou, Andriana I.Porsbjerg, Celeste M.Torres-Duque, Carlos A.Christoff, George CPopov, Todor AHew, MarkPeters, MatthewGibson, Peter G.Maspero, Jorge FBergeron , CelineCerda, SaraidContreras Contreras, Elvia AngelicaChen, WenjiaSadatsafavi, Mohsen2024-07-162024-07-162024-07-01Lee, T Y, Price, D, Yadav, C P, Roy, R, Huey Mien, L L, Wang, E, Wechsler, M E, Jackson, D J, Busby, J, Heaney, L G, Pfeffer, P E, Mahboub, B, Perng, D W, Cosio, B G, Perez de Llano, L, Al-Lehebi, R, Larenas-Linnemann, D, Al-Ahmad, M, Rhee, C K, Iwanaga, T, Heffler, E, Canonica, G W, Costello, R W, Papadopoulos, N G, Papaioannou, A I, Porsbjerg, C M, Torres-Duque, C A, Christoff, G C, Popov, T A, Hew, M, Peters, M, Gibson, P G, Maspero, J F, Bergeron , C, Cerda, S, Contreras Contreras, E A, Chen, W & Sadatsafavi, M 2024, 'International variation in severe exacerbation rates in patients with severe asthma', Chest, vol. 166, no. 1, pp. 28-38. https://doi.org/10.1016/j.chest.2024.02.0290012-3692https://hdl.handle.net/2164/23809Acknowledgment Guarantor statement: Tae Yoon Lee, Wenjia Chen, and Mohsen Sadatsafavi are responsible for the content of the manuscript, including the data and analysis Funding information: This work was supported by Singapore Ministry of Education Tier 1 Grant (22-4820-A0001-0) and a grant from Genome Canada / Genome British Columbia (274CHI).11435001engasthmacountryheterogeneitypredictionsevere exacerbationR MedicineSupplementary Datahttps://ars.els-cdn.com/content/image/1-s2.0-S0012369224002642-mmc1.docxRJournal article10.1016/j.chest.2024.02.0291661