Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence

Richardson, Jonathan P.Mogavero, SeleneMoyes, David L.Blagojevic, MarianaKruger, ThomasVerma, Akash H.Coleman, Bianca M.Diaz, Jacinto De La CruzSchulz, DanielaPonde, Nicole O.Carrano, GiuliaKniemeyer, OlafWilson, Duncan JohnBader, OliverEnoui, Simona I.Ho, Jemima Yuer MayKichik, NessimGaffen, Sarah LHube, BernhardNaglik, Julian R.2018-01-262018-01-262018-01-23Richardson, J P, Mogavero, S, Moyes, D L, Blagojevic, M, Kruger, T, Verma, A H, Coleman, B M, Diaz, J D L C, Schulz, D, Ponde, N O, Carrano, G, Kniemeyer, O, Wilson, D J, Bader, O, Enoui, S I, Ho, J Y M, Kichik, N, Gaffen, S L, Hube, B & Naglik, J R 2018, 'Processing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulence', mBio, vol. 9, no. 1, e02178-17. https://doi.org/10.1128/mBio.02178-17http://hdl.handle.net/2164/9949Funding Information This work was supported by grants from the Biotechnology and Biological Sciences Research Council (BB-J016411-1, BB/N014677/1), Medical Research Council (MR/J008303/1, MR/M011372/1), FP7-PEOPLE-2013-Initial Training Network (606786), Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology (097377/Z/11/Z), and the National Institute for Health Research at Guys and St Thomas's NHS Foundation Trust and King's College London Biomedical Research Centre to JRN; the Leibniz ScienceCampus InfectoOptics SAS-2015- HKI-LWC to BH, the Deutsche Forschungsgemeinschaft (TR/CRC FungiNet, project C1 and Z2) to BH and OK, the Infect ERA-NET Program (FunComPath; BMBF 031L0001A) to BH and SM; and the National Institutes of Health (NIH; DE022550) to SLG. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Acknowledgments We thank Dr. Selvam Thavaraj for helpful discussions and Dr. Sascha Brunke for developing the “Alignator” tool that allowed us to quickly analyse LC-MS/MS output files.1410164engcandida albicanscandidalysinfungal infectionkexinmucosal immunityR MedicineBiotechnology and Biological Sciences Research Council (BBSRC)BB-J016411-1BB/N014677/1Medical Research Council (MRC)MR/J008303/1MR/M011372/1European Commission606786Wellcome Trust097377/Z/11/ZNational Institute for Health Research (NIHR)RProcessing of Candida albicans Ece1p is critical for Candidalysin maturation and fungal virulenceJournal article10.1128/mBio.02178-1791