Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation

Sang, YaqiuLee, Robert HLuong, AnnieKatona, ÉvaWhyte, Claire SSmith, Nicholas LMast, Alan EFlick, Matthew JMutch, Nicola JBergmeier, WolfgangWolberg, Alisa S2024-10-112024-10-112024-10-08Sang, Y, Lee, R H, Luong, A, Katona, É, Whyte, C S, Smith, N L, Mast, A E, Flick, M J, Mutch, N J, Bergmeier, W & Wolberg, A S 2024, 'Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation', Blood Advances, vol. 8, no. 19, 2024012979, pp. 5072–5085. https://doi.org/10.1182/bloodadvances.20240129792473-9529ORCID: /0000-0001-8127-6102/work/166226933ORCID: /0000-0002-7452-0813/work/169538857https://hdl.handle.net/2164/24380The authors thank László Muszbek for the polyclonal anti-FXIII-Aantibody,Abigail R. Ballardfor technical support, Pablo Ariel for help with the immunofluorescence imaging and analysis, Marina Sokolsky for help with nanoparticle tracking analysis,and Nigel Mackman and Kadri Kangro for reading the manuscript.The Microscopy Services Laboratory, Department of Pathology and Laboratory Medicine, is supported in part by a Cancer Center Core Support Grant to the UNC Lineberger Comprehensive Cancer Center(P30 CA016086).143220706engSubstantive connection via an eligible employment contractSDG 3 - Good Health and Well-beingPlatelets and ThrombopoiesisThrombosis and HemostasisR Medicine (General)R1Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradationJournal article10.1182/bloodadvances.2024012979http://www.scopus.com/inward/record.url?scp=85206335879&partnerID=8YFLogxK819