Price, David B.Gefen, EranGopalan, GokulMcDonald, RosieThomas, VickyYau Ming, Simon WanDavis, Emily2018-02-192018-02-192018-01-24Price, D B, Gefen, E, Gopalan, G, McDonald, R, Thomas, V, Yau Ming, S W & Davis, E 2018, 'Real-life effectiveness and safety of salbutamol Steri-Neb™ vs. Ventolin Nebules ® for exacerbations in patients with COPD : Historical cohort study', PloS ONE, vol. 13, no. 1, e0191404. https://doi.org/10.1371/journal.pone.01914041932-6203http://hdl.handle.net/2164/10055This study was sponsored and funded by Teva Branded Pharmaceutical Products, R&D, Inc (Frazer, PA). The study was designed by academic investigators and by representatives of the sponsor, Teva Branded Pharmaceutical Products, R&D, Inc. Statistical analysis was completed by investigator VT. All authors contributed to the interpretation of data and writing or critically reviewing and revising the manuscript. All authors had access to the data and take complete responsibility for the integrity of the data and accuracy of the data analysis. The corresponding author had full access to all of the data and had final responsibility to submit for publication. This manuscript was prepared according to the International Society for Medical Publication Professionals’ Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP3. Data Availability: All relevant data are within the paper, and unmatched data for all outcomes is provided in the Supporting Information files. The dataset supporting the conclusions of this article was derived from the Clinical Practice Research Datalink (www.cprd.com) and the UK Optimum Patient Care Research Database (www.opcrd.co.uk). The authors do not have permission to give public access to these databases; however, researchers may request access for their own purposes. The CPRD has broad National Research Ethics Service Committee (NRES) ethics approval for purely observational research using the primary care data and established data linkages. The OPCRD has ethical approval from the National Health Service (NHS) Research Authority to hold and process anonymized research data (Research Ethics Committee reference: 15/EM/0150). This study was approved by the Anonymised Data Ethics Protocols and Transparency (ADEPT) Committee—the independent scientific advisory committee for the OPCRD, commissioned by the Respiratory Effectiveness Group—and the Independent Scientific Advisory Committee (ISAC) for the CPRD. The study was designed, implemented, and registered in accordance with the criteria of the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCEPP/SDPP/7645).4718707engR MedicineGeneral Biochemistry,Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesRJournal article10.1371/journal.pone.0191404http://www.scopus.com/inward/record.url?scp=85041121529&partnerID=8YFLogxK131