A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency

Westbury, Sarah K.Whyte, Claire S.Stephens, JonathanDownes, KateTurro, ErnestClaesen, KarenMertens, Joachim CHendriks, DirkLatif, Anne‐LouiseLeishman, Emma JNIHR BioResourceMutch, Nicola J.Campbell Tait, R.Mumford, Andrew D.2020-09-082020-09-082020-09Westbury, S K, Whyte, C S, Stephens, J, Downes, K, Turro, E, Claesen, K, Mertens, J C, Hendriks, D, Latif, AL, Leishman, E J, NIHR BioResource, Mutch, N J, Campbell Tait, R & Mumford, A D 2020, 'A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency', Journal of Thrombosis and Haemostasis, vol. 18, no. 9, pp. 2209-2214. https://doi.org/10.1111/jth.149901538-7933ORCID: /0000-0001-8127-6102/work/101050685ORCID: /0000-0002-7452-0813/work/169538847https://hdl.handle.net/2164/15105ACKNOWLEDGEMENTS We thank NIHR BioResource volunteers for their participation, and gratefully acknowledge NIHR BioResource centres, NHS Trusts and staff for their contribution. We thank the National Institute for Health Research and NHS Blood and Transplant. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. S.K.W. was supported during this work by the Medical Research Council (MR/K023489/1) and is now funded through an NIHR-funded Academic Clinical Lectureship. K.D. is supported as a HSST trainee by NHS Health Education England. N.J.M. and C.S.W. are supported by the British Heart Foundation (PG/15/82/31721). J.C.M. is a fellow of the Research Foundation Flanders (FWO Vlaanderen; 1137717N). A.D.M. is supported by the NIHR Biomedical Research Centre at the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol. We thank Prof Paul Declerck and Prof Ann Gils, University Leuven, Belgium for the kind gift of the MA-T12D11 antibody. We acknowledge technical assistance from Dorien Leenaerts, University of Antwerp, Belgium and Michela Donnarumma, University of Aberdeen, UK.6848625engThrombomodulinBleedingFibrinolysisGenomicsTAFI (carboxypeptidase B2 (CPB2)/procarboxypeptidase U (proCPU))fibrinolysisbleedingthrombomodulingenomicsTAFI (carboxypeptidase B2 [CPB2]/procarboxypeptidase U [proCPU])LYSISprocarboxypeptidase U [proCPU])DISORDERTAFI (carboxypeptidase B2 [CPB2]R MedicineHematologyMedical Research Council (MRC)MR/K023489/1OtherBritish Heart FoundationPG/15/82/31721Supplementary DataRA new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiencyJournal article10.1111/jth.14990http://www.scopus.com/inward/record.url?scp=85088364370&partnerID=8YFLogxK189