Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake

d'Agostino, GiuseppeLyons, DavidCristiano, ClaudiaLettieri, MiriamOlarte-Sanchez, CristianBurke, Luke K.Greenwald-Yarnell, MeganCansell, CelineDoslikova, BarboraGeorgescu, TeodoraBlanco Martinez de Morentin, PabloMyers Jr., Martin GRochford, Justin J.Heisler, Lora K.2018-08-312018-08-312018-10-02d'Agostino, G, Lyons, D, Cristiano, C, Lettieri, M, Olarte-Sanchez, C, Burke, L K, Greenwald-Yarnell, M, Cansell, C, Doslikova, B, Georgescu, T, Blanco Martinez de Morentin, P, Myers Jr., M G, Rochford, J J & Heisler, L K 2018, 'Nucleus of the Solitary Tract Serotonin 5-HT 2C Receptors Modulate Food Intake', Cell Metabolism, vol. 28, no. 4, pp. 619-630.e5. https://doi.org/10.1016/j.cmet.2018.07.0171550-4131ORCID: /0000-0002-5020-4939/work/53729102http://hdl.handle.net/2164/11021The authors wish to thank members of staff of the Medical Research Facility, University of Aberdeen, Ms. Raffaella Chianese and Dr. Susan Jalicy, for technical assistance. PX330 and PX552 plasmids were a gift from Prof. Feng Zhang (Massachusetts Institute of Technology, Massachusetts, USA). DREADD vectors were a gift from Prof. Bryan Roth (University of North Carolina at Chapel Hill, North Carolina, USA). PomcDsRED and PomcNEO mice were a gift from Prof. Malcolm Low (University of Michigan, Michigan, USA). Codes to analyze operant-responding for food were a gift from Dr. Vladimir Orduña Trujillo (National Autonomous University of Mexico, Mexico). This work was supported by the Wellcome Trust (L.K.H.; WT098012), Wellcome Trust and the University of Aberdeen (G.D.; 105625/Z/14/Z), Biotechnology and Biological Sciences Research Council (L.K.H., BB/K001418/1, BB/N017838/1; and J.J.R., BB/K017772/1), Medical Research Council (J.J.R., MR/L002620/1; G.D., MR/P009824/1; L.K.H., J.J.R., G.D., MC/PC/15077), British Society of Neuroendocrinology (G.D.), NIH and the Marilyn H. Vincent Foundation (M.G.M.; DK056731, DK034933).184747226engSDG 3 - Good Health and Well-beingserotonin5-HT2CRlorcaserinfood intakenucleus of the solitary tractobesityR Medicine (General)Wellcome Trust105625/Z/14/ZWT098012Biotechnology and Biological Sciences Research Council (BBSRC)BB/K001418/1BB/N017838/1BB/K017772/1Medical Research Council (MRC)MR/L002620/1MR/P009824/1MC/PC/15077Supplementary DataR1Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food IntakeJournal article10.1016/j.cmet.2018.07.017https://www.cell.com/rights-sharing-embargoes284