Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

Leeson-Payne, AlasdairIyinikkel, JeanMalcolm, CameronLam, Brian Y HSommer, NadineDowsett, Georgina K CBlanco Martinez de Morentin, PabloThompson, DawnMacKenzie, AlasdairChianese, RaffaellaKentistou, Katherine AGardner, Eugene J.Perry, John R.B.Grassmann, FelixSpeakman, JohnRochford, JustinYeo, Giles S. H.Murray, FionaHeisler, Lora2024-06-132024-06-132024-05-07Leeson-Payne, A, Iyinikkel, J, Malcolm, C, Lam, B Y H, Sommer, N, Dowsett, G K C, Blanco Martinez de Morentin, P, Thompson, D, MacKenzie, A, Chianese, R, Kentistou, K A, Gardner, E J, Perry, J R B, Grassmann, F, Speakman, J, Rochford, J, Yeo, G S H, Murray, F & Heisler, L 2024, 'Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation', Cell Metabolism, vol. 36, no. 5, pp. 1076-1087. https://doi.org/10.1016/j.cmet.2024.03.0161550-4131ORCID: /0000-0003-0948-9458/work/160846872ORCID: /0000-0002-1823-2913/work/160846988ORCID: /0000-0003-2380-7117/work/160847125ORCID: /0000-0003-1390-7528/work/160847673ORCID: /0000-0002-5020-4939/work/160848134ORCID: /0000-0002-5572-4810/work/160848192https://hdl.handle.net/2164/23598Open Access via the Elsevier Agreement L.K.H. designed the experiments with input from F.M., G.S.H.Y., and J.J.R.; F.M. and J.I. created the CRISPR-Cas9-deleted Gpr75 mouse line with input from A.M.; A.L.-P., C.M., B.Y.H.L., G.K.C.D., N.S., P.B.M.d.M., R.C., K.K., E.J.G., J.R.B.P., F.G., J.R.S., and J.J.R. performed experiments and/or data analysis; D.T. provided reagents and intellectual contributions; and L.K.H. and A.L.-P. wrote the manuscript with input from all other authors.124553585engSDG 3 - Good Health and Well-beingG protein-coupled receptorGpr75NAFLDobesityphysical activityfatty liverRC Internal medicineSupplementary Informationhttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc1.pdfhttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc2.xlsxhttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc3.ziphttps://ars.els-cdn.com/content/image/1-s2.0-S1550413124001207-mmc4.pdfRCLoss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulationJournal article10.1016/j.cmet.2024.03.016365