Mandal, SemaSimmons, RuthIreland, GeorginaCharlett, AndreDesai, MonicaCoughlan, LauraPowell, AnnabelLeeman, DavidWilliams, ChristopherNeill, ClaireO'Leary, Maureen C.Sawyer, ClareRowley, FrancesHarris, CarolineHoulihan, CatherineGordon, ClaireRampling, TommyCallaby, HelenHoschler, KatjaCogdale, JadeRenz, ErikSebastianpilli, PraveenThompson, CatherineTalts, TiinaCelma, CristinaDavies, Emma A.Ahmad, ShazaadMachin, NicholasGifford, LauraMoore, CatherineDickson, Elizabeth M.Divala, Titus H.Henderson, DavidLi, KathyBroadbent, PhilipUshiro-Lumb, InesHumphreys, ClareGrammatikopoulos, TassosHartley, JaneKelgeri, ChayaraniRajwal, SanjayOkike, IfeanyichukwuKelly, Deirdre A.Guiver, MalcolmBorrow, RayBindra, RenuDemirjian, AliciaBrown, Kevin E.Ladhani, Shamez N.Ramsay, Mary E.Bradley, Declan T.Gjini, ArdianaRoy, KirstyChand, MeeraZambon, MariaWatson, Conall H.2024-02-152024-02-152023-11Mandal, S, Simmons, R, Ireland, G, Charlett, A, Desai, M, Coughlan, L, Powell, A, Leeman, D, Williams, C, Neill, C, O'Leary, M C, Sawyer, C, Rowley, F, Harris, C, Houlihan, C, Gordon, C, Rampling, T, Callaby, H, Hoschler, K, Cogdale, J, Renz, E, Sebastianpilli, P, Thompson, C, Talts, T, Celma, C, Davies, E A, Ahmad, S, Machin, N, Gifford, L, Moore, C, Dickson, E M, Divala, T H, Henderson, D, Li, K, Broadbent, P, Ushiro-Lumb, I, Humphreys, C, Grammatikopoulos, T, Hartley, J, Kelgeri, C, Rajwal, S, Okike, I, Kelly, D A, Guiver, M, Borrow, R, Bindra, R, Demirjian, A, Brown, K E, Ladhani, S N, Ramsay, M E, Bradley, D T, Gjini, A, Roy, K, Chand, M, Zambon, M & Watson, C H 2023, 'Paediatric acute hepatitis of unknown aetiology : a national investigation and adenoviraemia case-control study in the UK', The Lancet Child and Adolescent Health, vol. 7, no. 11, pp. 786-796. https://doi.org/10.1016/S2352-4642(23)00215-82352-4642ORCID: /0009-0005-1458-4857/work/162252545https://hdl.handle.net/2164/22765Funding Information: This work was undertaken as part of a national enhanced incident by UK public health agencies. We thank the parents and guardians of the children who gave up their valuable time to speak to the public health investigation teams; without their support we could not have been able to undertake a thorough investigation. We are grateful to the many paediatricians and liver specialists who reported cases to us and responded to follow-up with further information. We also thank Ezra Linley and Simon Tonge of the UK Health Security Agency Seroepidemiology Unit for rapidly providing serum samples for testing. We would like to thank the Incident Management Teams of the UK nations, members of the incident cells, epidemiology, laboratory, and local Health Protection Teams who supported the investigations, in particular: Katy Sinka, Mike Gent, Suzanna Howes, Eileen Gallagher, Selene Corsini, Eleanor Clarke, Rajani Raghu, Kelsey Mowat, Iain Hayden, Matt Hibbert, Skye Firminger, Catriona Angel, Donna Haskins, Kay Ratcliffe, Hannah Emmett, Alex Elliot, Helen Hughes, Sarah Deeny, Sarah Garner, Sarah Gerver, Flora Stevens, Paula Blomquist, Gabriel Gurmail Kauffman, Kristine Cooper, Hannah Taylor, Giovanni Leonardi, Michelle Dickinson and Michelle Watson from England; Kimberly Marsh, Michael Lockhart, David Yirrell, Sandra Currie, Kate Templeton, Samantha Shepherd, Roisin Ure, Jim McMenamin, Rachel Tayler, Louisa Pollock, Antonia Ho, Chris Cunningham and Hayley Peacock from Scotland; and Katie Binley and Meg Wallace from Northern Ireland.11369243engNo substantive connection to the University of AberdeenSDG 3 - Good Health and Well-beingChild, PreschoolFemaleHumansMaleAcute DiseaseCase-Control StudiesCOVID-19HepatitisSARS-CoV-2United Kingdom/epidemiologyRJ PediatricsDevelopmental and Educational PsychologyPediatrics, Perinatology, and Child HealthRJJournal article10.1016/S2352-4642(23)00215-8http://www.scopus.com/inward/record.url?scp=85173827832&partnerID=8YFLogxK711