Bernal, JoseValdés-Hernández, Maria d.C.Escudero, JavierHeye, Anna K.Sakka, EleniArmitage, Paul A.Makin, StephenTouyz, Rhian M.Wardlaw, Joanna M.Thrippleton, Michael J.2021-02-022021-02-022021-04-15Bernal, J, Valdés-Hernández, M D C, Escudero, J, Heye, A K, Sakka, E, Armitage, P A, Makin, S, Touyz, R M, Wardlaw, J M & Thrippleton, M J 2021, 'A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage', Neuroimage, vol. 230, 117786. https://doi.org/10.1016/j.neuroimage.2021.1177861053-8119RIS: urn:6CDB068283DD6821F1C310FEFE00866DORCID: /0000-0001-8701-9043/work/88320462Jisc: 381e54e24bc648a2b5e46bf0832a792dhttps://hdl.handle.net/2164/15763Acknowledgements This work is supported by the MRC Doctoral Training Programme in Precision Medicine (JB); the Wellcome Trust (patient recruitment, scanning, and primary study - Reference No. WT088134/Z/09/A); the UK Dementia Research Institute, which receives its funding from DRI Ltd, funded by the UK MRC, Alzheimer’s Society, and Alzheimer’s Research UK; the Fondation Leducq Network for the Study of Perivascular Spaces in Small Vessel Disease (16 CVD 05); The Row Fogo Charitable Trust Centre for Research into ageing and the Brain (MVH) (BRO-D.FID3668413); a British Heart Foundation Chair award (RMT) (CH/12/4/29762); and NHS Lothian Research and Development Office (MJT); European Union Horizon 2020, PHC-03-15, project No666881. We thank the participants, their families, radiographers at Edinburgh Imaging, and the Stroke Research Network at the University of Edinburgh.125639670engDigital reference objectBlood-brain barrier permeabilityDCE-MRISpatio-temporal imaging artefactsEndothelial dysfunctionCerebral small vessel diseaseNeurologyCognitive NeuroscienceR MedicineNeurologyCognitive NeuroscienceOtherBRO-D.FID3668413British Heart FoundationCH/12/4/29762Arthritis Research UK (ARUK)Wellcome TrustWT088134/Z/09/ASupplementary DataRJournal article10.1016/j.neuroimage.2021.117786http://www.scopus.com/inward/record.url?scp=85100055127&partnerID=8YFLogxK230