Singh, Abhay NarayanOehler, JudithTorrecilla, IgnacioKilgas, SusanLi, ShudongVaz, BrunoGuérillon, ClaireFielden, JohnHernandez-Carralero, EsperanzaCabrera, ElisaTullis, Iain D.C.Meerang, MayuraBarber, Paul R.Freire, RaimundoParsons, JasonVojnovic, BorivojKiltie, Anne E.Mailand, NielsRamadan, Kristijan2024-04-152024-04-152019-11-04Singh, A N, Oehler, J, Torrecilla, I, Kilgas, S, Li, S, Vaz, B, Guérillon, C, Fielden, J, Hernandez-Carralero, E, Cabrera, E, Tullis, I D C, Meerang, M, Barber, P R, Freire, R, Parsons, J, Vojnovic, B, Kiltie, A E, Mailand, N & Ramadan, K 2019, 'The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8', EMBO Journal, vol. 38, no. 21, e102361. https://doi.org/10.15252/embj.20191023610261-4189ORCID: /0000-0001-7208-2912/work/114166765https://hdl.handle.net/2164/23241Funding Information: The Ramadan Laboratory is supported by a Medical Research Council UK programme grant (MC_EX_MR/K022830/1) to K.R. J.O. was supported by a Swiss National Science Foundation grant (31003A_141197) to K.R., a Goodger and Schorstein Scholarship, University of Oxford, and a European Institute of Innovation and Technology short-term post-doctoral fellowship. S. K, J. F. and S. L were supported by the Cancer Research UK or MRC studentships. B. Vo., A. E. K. and I. D. C. T. are supported by Cancer Research UK Programme Grant C5255/A15935. C.G. was supported by the Danish Cancer Society (Grant No. R146-RP11394). R. F. is supported by Spanish Ministry of Innovation Science and Universities/EU-ERDF (SAF2016-80626-R), E. C. is supported by the Fundaci?n DISA, and E. H-C. is supported by an ACIISI pre-doctoral fellowship. We thank Ross Chapman for providing us with WT and 53BP1-deficient MCF7 cell lines. We are grateful to Pam Reynolds for support with the UV micro-irradiation system, to the Mechanical and Electronics Workshops (J Prentice and RG Newman) for assistance with construction of the system, to the Bioanalysis Core (Graham Brown and Ioland Vendrell) for the supports with microscopy and mass spectrometry and to the Radiation Biophysics Core for the help with X-ray radiation. We thank Benedikt Kessler for his constant support with mass spectrometry. We thank Jeremy Stark for providing us with GFP-reporter assays for HR and NHEJ.257686636engSDG 3 - Good Health and Well-beingAtaxin 3DNA double-strand break repairE3 ubiquitin ligase RNF8genome stabilityp97/VCP ATPaseR MedicineGeneral NeuroscienceMolecular BiologyGeneral Biochemistry,Genetics and Molecular BiologyGeneral Immunology and MicrobiologyMedical Research Council (MRC)MC_EX_MR/K022830/1Cancer Research UKC5255/A15935RJournal article10.15252/embj.2019102361http://www.scopus.com/inward/record.url?scp=85074272876&partnerID=8YFLogxK3821