Rupprechter, SamuelRomaniuk, LianaSeries, PeggyHirose, TakehiroHawkins, EmmaSandu-Giuraniuc, Anca-LarisaWaiter, Gordon DMcNeil, Christopher JShen, XueyiHarris, Mathew A.Campbell, ArchiePorteous, DavidMacfarlane, Jennifer A.Lawrie, Stephen M.Murray, Alison DDelgado, Mauricio RMcIntosh, Andrew M.Whalley, Heather C.Steele, J Douglas2020-05-222020-05-222020-06-01Rupprechter, S, Romaniuk, L, Series, P, Hirose, T, Hawkins, E, Sandu-Giuraniuc, A-L, Waiter, G D, McNeil, C J, Shen, X, Harris, M A, Campbell, A, Porteous, D, Macfarlane, J A, Lawrie, S M, Murray, A D, Delgado, M R, McIntosh, A M, Whalley, H C & Steele, J D 2020, 'Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression', Brain, vol. 143, no. 6, pp. 1946-1956. https://doi.org/10.1093/brain/awaa1060006-8950ORCID: /0000-0002-5313-9845/work/74712221ORCID: /0000-0003-4915-4847/work/76976578ORCID: /0000-0002-5555-4129/work/79062148https://hdl.handle.net/2164/14354Stratifying Resilience and Depression Longitudinally (STRADL) was supported by the Wellcome Trust through a Strategic Award (Grant No. 104036/Z/14/Z). Parts of the work were supported by a China Scholarship Council (Grant No. 201506040037 to SX), National Institutes of Health (Grant No. DA027764 to MRD), Lister Institute Prize Fellowship 2016–2021 (to DJS), Dr Mortimer and Theresa Sackler Foundation (AMM, HCW, and SML), Centre for Cognitive Ageing and Cognitive Epidemiology (IJD and AMM), Medical Research Council and Biotechnology and Biological Sciences Research Council (Grant No. MR/K026992/1), Royal College of Physicians of Edinburgh John, Margaret, Alfred and Stewart Sim fellowship (to HCW), and University of Edinburgh, Edinburgh Scientific Academic TmPCk College Fellowship (to HCW). The Chief Scientist Office of the Scottish Government Health Department (Grant No. CZD/16/6) and Scottish Funding Council (Grant No. HR03006) provided core support for Generation Scotland. Data acquisition was additionally supported by the Scottish Mental Health Research Network and Scottish Government’s Support for Science initiative. LR, HCW, and AMM, received financial support from Pfizer (formerly Wyeth) in relation to imaging studies of people with schizophrenia and bipolar disorder. AMM has previously received grant support from Lilly and Janssen. SML has received honoraria for lectures, chairing meetings, and consultancy work from Janssen in connection with brain imaging and therapeutic initiatives for psychosis. JDS has received funding via an honorarium associated with a lecture or Wyeth and funding from Indivior for a study on opioid dependency. No other disclosures were reported. The authors declare no conflict of interest.11841205engRDoCeffective connectivityreinforcement learningmodel-based fMRIreward prediction errorMDDDCMRC0321 Neuroscience. Biological psychiatry. NeuropsychiatryClinical NeurologyScottish Funding CouncilCZD/16/6HR03006Medical Research Council (MRC)MR/K026992/1National Institute for Health Research (NIHR)DA027764Wellcome Trust104036/Z/14/Z201506040037RC0321Journal article10.1093/brain/awaa106http://www.scopus.com/inward/record.url?scp=85086682141&partnerID=8YFLogxK1436