The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress

Watts, Lotte PNatsume, ToyoakiSaito, YuichiroGarzon, JavierDong, QianqianBoteva, LoraGilbert, NickKanemaki, Masato THiraga, Shin-IchiroDonaldson, Anne D2021-04-122021-04-122020-11-03Watts, L P, Natsume, T, Saito, Y, Garzon, J, Dong, Q, Boteva, L, Gilbert, N, Kanemaki, M T, Hiraga, S-I & Donaldson, A D 2020, 'The RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress', eLife, vol. 9, e58020. https://doi.org/10.7554/eLife.58020ORCID: /0000-0002-8722-3869/work/83310244ORCID: /0000-0002-5093-8385/work/83311016unpaywall: 10.7554/elife.58020https://hdl.handle.net/2164/16226Acknowledgements Thanks to members of the Aberdeen Chromosome Biology Group for helpful comments, and Ronan Broderick and Wojciech Niedzwiedz for advice on mitotic bridge analysis. We thank Raif Yuecel and his team at the Iain Fraser Cytometry Centre for assistance, and Kevin Mackenzie and his team at the Microscopy and Histology Core Facility. Work was supported by Cancer Research UK Studentship Award C1445/A20596 and CRUK Programme Award C1445/A19059; by JSPS KAKENHI Grants Numbers 17K15068, 18H02170 and 18H04719; by research grants from the Daiichi Sankyo’s Foundation of Life Science and the Takeda Science Foundation; and by the UK Medical Research Council (MC_UU_00007/13). Collaboration was supported by a 2017 JSPS Summer Programme Fellowship. Funding Cancer Research UK (C1445/A20596) Anne D Donaldson Cancer Research UK (C1445/A19059) Anne D Donaldson Japan Society for the Promotion of Science (17K15068) Masato T Kanemaki Japan Society for the Promotion of Science (18H02170) Masato T Kanemaki Japan Society for the Promotion of Science (18H04719) Masato T Kanemaki Medical Research Council (MC_UU_00007/13) Nick Gilbert262452490engSDG 3 - Good Health and Well-beingRIF1DNA replicationDNA replication stressSplicingreplication stresscell biologychromosomessplicinghumangene expressionR MedicineGeneral Immunology and MicrobiologyGeneral Biochemistry,Genetics and Molecular BiologyGeneral NeuroscienceMedical Research Council (MRC)MC_UU_00007/13Cancer Research UKC1445/A20596C1445/A19059RThe RIF1-Long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stressJournal article10.7554/eLife.58020http://www.scopus.com/inward/record.url?scp=85096362949&partnerID=8YFLogxK9