Mazzon, MichelaCastro, CeciliaThaa, BastianLiu, LifengMutso, MargitLiu, XiangMahalingam, SureshGriffin, Julian LMarsh, MarkMcInerney, Gerald M2021-11-262021-11-262018-01-29Mazzon, M, Castro, C, Thaa, B, Liu, L, Mutso, M, Liu, X, Mahalingam, S, Griffin, J L, Marsh, M & McInerney, G M 2018, 'Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes', PLoS Pathogens, vol. 14, no. 1, e1006835. https://doi.org/10.1371/journal.ppat.10068351553-7366PubMedCentral: PMC5805360ORCID: /0000-0003-1336-7744/work/98038723https://hdl.handle.net/2164/17568Acknowledgments We thank our MRC-LMCB colleagues Dr Chiara Mencarelli who provided the rat cortical neurons used in this study, Dr Christin Luft for help with acquisition of high-content confocal images, and Dr Janos Kriston-Vizi for help with Fiji software. Dr Scott Lawrence kindly provided the SH-SY5Y cells. We thank Prof Andres Merits (University of Tartu, Estonia) for provision of nsP3 antibody and Dr Ji Luo (National Cancer Institute, USA) for provision of p85 expression plasmids.229281737engAlphavirus/pathogenicityAlphavirus Infections/metabolismAnimalsCells, CulturedCricetinaeEnzyme ActivationGlucose/metabolismGlycolysis/physiologyHEK293 CellsHost-Pathogen InteractionsHumansMiceMice, Inbred C57BLPhosphatidylinositol 3-Kinases/metabolismProto-Oncogene Proteins c-akt/metabolismRoss River virus/physiologySemliki forest virus/physiologyVirulenceQR355 VirologyMedical Research Council (MRC)MC_UU_12018/1MC_UP_A090_1006Supplementary InformationQR355Journal article10.1371/journal.ppat.1006835141