Hypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling

Pradhan, ArnabAvelar, Gabriela M.Bain, Judith M.Childers, Delma SLarcombe, Daniel E.Netea, Mihai G.Shekhova, ElenaMunro, Carol A.Brown, Gordon D.Erwig, Lars P.Gow, Neil A. R.Brown, Alistair J. P.2018-11-092018-11-092018-11-06Pradhan, A, Avelar, G M, Bain, J M, Childers, D S, Larcombe, D E, Netea, M G, Shekhova, E, Munro, C A, Brown, G D, Erwig, L P, Gow, N A R & Brown, A J P 2018, 'Hypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A Signaling', mBio, vol. 9, e01318-18. https://doi.org/10.1128/mBio.01318-18ORCID: /0000-0002-2776-5850/work/52609430ORCID: /0000-0003-2869-7332/work/76975989ORCID: /0000-0002-1060-0419/work/112075856ORCID: /0000-0003-0761-1755/work/162729079http://hdl.handle.net/2164/11411We are very grateful to the members of our Iain Fraser Cytometry Centre and Microscopy and Histology Core Facility for their superb help, advice and support. We also thank our generous colleagues in the Candida community, and in particular Ana Traven, Jan Quinn, Guanghua Huang, Suzanne Noble, Donna MacCallum, Liz Johnson, Karl Kuchler, Patrick van Dijck, Rich Calderone and Malcolm Whiteway for providing strains used in this study. This work was funded by grants from the UK Medical Research Council [www.mrc.ac.uk], to AJPB, NARG, LPE, MN (MR/M026663/1), and by PhD studentships from the University of Aberdeen to AP, DL. The work was also supported by the Wellcome Trust [www.wellcome.ac.uk], NARG, GDB, AJPB (097377) and GDB (102705); and by the Medical Research Council Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.184285442enghypoxiaCandida albicanscell wallβ-glucan maskingmitochondrial signallingcAMP-protein kinase A signallingR Medicine (General)Medical Research Council (MRC)MR/M026663/1MR/N006364/1Wellcome Trust097377102705Supplementary DataR1Hypoxia Promotes Immune Evasion by Triggering β-glucan Masking on the Candida albicans Cell Surface via Mitochondrial and cAMP-Protein Kinase A SignalingJournal article10.1128/mBio.01318-189