Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

Testa, AndreaDall'Angelo, SergioMingarelli, MarcoAugello, AndreaSchweiger, LutzWelch, Andrew EdwardElmore, Charles S.Sharma, PradeepZanda, Matteo2017-12-102017-12-102017-02-01Testa, A, Dall'Angelo, S, Mingarelli, M, Augello, A, Schweiger, L, Welch, A E, Elmore, C S, Sharma, P & Zanda, M 2017, 'Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters', Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976. https://doi.org/10.1016/j.bmc.2016.12.0080968-0896ORCID: /0000-0001-9377-0474/work/176747535http://hdl.handle.net/2164/9754We thank Dr Dana Dawson and Dr Gabriella Baio for support and advice with PET imaging experiments. A.T. gratefully acknowledges SINAPSE (www.sinapse.ac.uk) and AstraZeneca (UK) for co-funding a studentship. P.S. and C.S.E. are employees of AstraZeneca Ltd., UK.142282717engfluorinebile acidsliver transportersPET imagingtritiumpreclinical studyclick chemistryclearanceR MedicineRDesign, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transportersJournal article10.1016/j.bmc.2016.12.008253