Individuals With High Bone Mass Have Increased Progression of Radiographic and Clinical Features of Knee Osteoarthritis

Hartley, April E.Hardcastle, Sarah A.Paternoster, LaviniaMcCloskey, EugenePoole, Kenneth E. S.Javaid, Muhammad K.Aye, MoMoss, KatieGranell, RaquelGregory, JennyWilliams, MartinTobias, Jon H.Gregson, Celia L.2021-05-132021-05-132020-09Hartley, A E, Hardcastle, S A, Paternoster, L, McCloskey, E, Poole, K E S, Javaid, M K, Aye, M, Moss, K, Granell, R, Gregory, J, Williams, M, Tobias, J H & Gregson, C L 2020, 'Individuals With High Bone Mass Have Increased Progression of Radiographic and Clinical Features of Knee Osteoarthritis', Osteoarthritis and Cartilage, vol. 28, no. 9, pp. 1180-1190. https://doi.org/10.1016/j.joca.2020.03.0201063-4584https://hdl.handle.net/2164/16459Acknowledgements: We would like to thank all our HBM study participants and the staff at the University of Bristol and our collaborating centres: Addenbrooke’s Wellcome Trust Clinical Research Facility, NIHR Bone Biomedical Research Unit in Sheffield, the Centre for Metabolic Bone Disease in Hull, Southmead Hospital in Bristol, Nuffield Orthopaedic Centre in Oxford, the Royal National Hospital for Rheumatic Diseases in Bath and St George’s Hospital in London. Role of the funding source: The HBM study was supported by The Wellcome Trust (080280/Z/06/Z), the National Institute for Health Research Clinical Research Network (portfolio no. 5163) and Versus Arthritis (ref 20000). AH is funded by the Wellcome Trust (grant ref 20378/Z/16/Z). Follow-up imaging at the Hull site was funded by OSPREY (OSteoPorosis Research in East Yorkshire). AH, LP, JHT and CLG work in, or are affiliated with, a University of Bristol and MRC funded unit (MC_UU_00011/1).11486961engosteoarthritisprogressionhigh bone massBMDWOMAChealth-related quality of lifeProgressionHealth-related quality of lifeHigh bone massOsteoarthritisSTANDARDIZATIONINCIDENTINCREASED PREVALENCERISKHIPREPLACEMENTWOMENMINERAL DENSITYELDERLY-MENASSOCIATIONR Medicine (General)Biomedical EngineeringRheumatologyOrthopedics and Sports MedicineMedical Research Council (MRC)MC_UU_00011/1National Institute for Health Research (NIHR)5163Wellcome Trust080280/Z/06/Z20378/Z/16/ZR1Individuals With High Bone Mass Have Increased Progression of Radiographic and Clinical Features of Knee OsteoarthritisJournal article10.1016/j.joca.2020.03.020http://www.scopus.com/inward/record.url?scp=85086726634&partnerID=8YFLogxK289