Hager, Karen JPérez Marc, GonzaloGobeil, PhilipeDiaz, Ricardo SHeizer, GretchenLlapur, ConradoMakarkov, Alexander IVasconcellos, EduardoPillet, StéphaneRiera, FernandoSaxena, PoojaGeller Wolff, PriscilaBhutada, KapilWallace, GarryAazami, HessamJones, Christine EPolack, Fernando PFerrara, LucianaAtkins, JudithBoulay, IohannDhaliwall, JiwanjeetCharland, NathalieCouture, Manon M JJiang-Wright, JuliaLandry, NathalieLapointe, SophieLorin, AurélienMahmood, AsifMoulton, Lawrence HPahmer, EmilyParent, JulieSéguin, AnnieTran, LuanBreuer, ThomasCeregido, Maria-AngelesKoutsoukos, MargueriteRoman, FrançoisNamba, JunyaD'Aoust, Marc-AndréTrepanier, SoniaKimura, YosukeWard, Brian JCoVLP Study Team2022-11-042022-11-042022-06-02Hager, K J, Pérez Marc, G, Gobeil, P, Diaz, R S, Heizer, G, Llapur, C, Makarkov, A I, Vasconcellos, E, Pillet, S, Riera, F, Saxena, P, Geller Wolff, P, Bhutada, K, Wallace, G, Aazami, H, Jones, C E, Polack, F P, Ferrara, L, Atkins, J, Boulay, I, Dhaliwall, J, Charland, N, Couture, M M J, Jiang-Wright, J, Landry, N, Lapointe, S, Lorin, A, Mahmood, A, Moulton, L H, Pahmer, E, Parent, J, Séguin, A, Tran, L, Breuer, T, Ceregido, M-A, Koutsoukos, M, Roman, F, Namba, J, D'Aoust, M-A, Trepanier, S, Kimura, Y, Ward, B J & CoVLP Study Team 2022, 'Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine', The New England Journal of Medicine, vol. 386, 2201300, pp. 2084-2096. https://doi.org/10.1056/NEJMoa22013000028-4793ORCID: /0000-0002-1397-4272/work/112886384https://hdl.handle.net/2164/19465Supported by Medicago with financial assistance from the Canadian Innovation, Science and Economic Development Strategic Innovation Fund. Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. We thank all the trial participants; the staff members at each site for their high degree of professionalism in the conduct of the trial; all the employees and contractors at Medicago and GSK for their support; and all the contributors to the GISAID initiative for generating the genetic sequences and metadata on which Figure S1 is based.131099704engSDG 3 - Good Health and Well-beingR MedicineSupplementary InformationRJournal article10.1056/NEJMoa2201300386