Porsbjerg, Celeste M.Townend, JohnBergeron , CelineChristoff, George CKatsoulotos, Gregory P.Larenas-Linnemann, DésiréeTran, Trung NAl-Lehebi, RiyadBosnic-Anticevich, Sinthia ZBusby, JohnHew, MarkKostikas, KonstantinosPapadopoulos, Nikolaos GPfeffer, Paul EPopov, Todor ARhee, Chin KookSadatsafavi, MohsenTsai, Ming-JuSuppli Ulrik, CharlotteAlAhmad, MonaAltraja, AlanBeastall, AaronBulathsinhala, LakminiCarter, VictoriaCosio, Borja G.Fletton, KirstyHansen, SusanneHeaney, Liam GHubbard, Richard B.Kuna, PiotrMurray, Ruth BNagano, TatsuyaPini, LauraCano-Rosales, Diana JimenaSchleich, FlorenceWechsler, Michael EAmaral, RitaBourdin, ArnaudBrusselle, GuyChen, WenjiaChung, Li PingDenton, EveFonseca, João A.Hoyte, Flavia L.Jackson, David JKatial, RohitKirenga, Bruce J.Koh, Mariko SiyueŁawkiedraj, AgnieszkaLehtimäki, LauriLiew, Mei FongMahboub, BassamMartin, NeilMenzies-Gow, AndrewHwee Pang, PeePapaioannou, Andriana I.Patel, Pujan HPerez de Llano, LuisPeters, Matthew JRicciardi, LuisaRodríguez-Cáceres, BellanidSolarte, IvanRen Tay, TunnTorres-Duque, Carlos A.Wang, EileenZappa, MartinaAbisheganaden, JohnAssing, Karin DahlCostello, Richard WGibson, Peter G.Heffler, EnricoMaspero, Jorge FNicola, StefaniaPerng, Diahn WarngPuggioni, FrancescaSalvi, SundeepSheu, Chau-ChyunSirena, ConcettaTaillé, CamilleTan, Tze LeeBjermer, LeifCanonica, Giorgio WalterIwanaga, TakashiJiménez-Maldonado, LibardoTaube, ChristianBrussino, LuisaPrice, David2024-04-192024-04-192024-04-19Porsbjerg, C M, Townend, J, Bergeron , C, Christoff, G C, Katsoulotos, G P, Larenas-Linnemann, D, Tran, T N, Al-Lehebi, R, Bosnic-Anticevich, S Z, Busby, J, Hew, M, Kostikas, K, Papadopoulos, N G, Pfeffer, P E, Popov, T A, Rhee, C K, Sadatsafavi, M, Tsai, M-J, Suppli Ulrik, C, AlAhmad, M, Altraja, A, Beastall, A, Bulathsinhala, L, Carter, V, Cosio, B G, Fletton, K, Hansen, S, Heaney, L G, Hubbard, R B, Kuna, P, Murray, R B, Nagano, T, Pini, L, Cano-Rosales, D J, Schleich, F, Wechsler, M E, Amaral, R, Bourdin, A, Brusselle, G, Chen, W, Chung, L P, Denton, E, Fonseca, J A, Hoyte, F L, Jackson, D J, Katial, R, Kirenga, B J, Koh, M S, Ławkiedraj, A, Lehtimäki, L, Liew, M F, Mahboub, B, Martin, N, Menzies-Gow, A, Hwee Pang, P, Papaioannou, A I, Patel, P H, Perez de Llano, L, Peters, M J, Ricciardi, L, Rodríguez-Cáceres, B, Solarte, I, Ren Tay, T, Torres-Duque, C A, Wang, E, Zappa, M, Abisheganaden, J, Assing, K D, Costello, R W, Gibson, P G, Heffler, E, Maspero, J F, Nicola, S, Perng, D W, Puggioni, F, Salvi, S, Sheu, C-C, Sirena, C, Taillé, C, Tan, T L, Bjermer, L, Canonica, G W, Iwanaga, T, Jiménez-Maldonado, L, Taube, C, Brussino, L & Price, D 2024, 'Association between pre-biologic T2-biomaker combinations and response to biologics in patients with severe asthma', Frontiers in Immunology, vol. 15. https://doi.org/10.3389/fimmu.2024.1361891, https://doi.org/10.3389/fimmu.2024.1361891/full#supplementary-material1664-3224https://hdl.handle.net/2164/23297Funding This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global (OPCG) and AstraZeneca Ltd. No funding was received by the OPRI for its contribution. The International Severe Asthma Registry (ISAR) is operated by OPCG and co-funded by OPCG and AstraZeneca3485606engSever asthmabiomarkersEOSINOPHIL (EOS)FeNO (Fraction of exhaled Nitric Oxide)biologicsFEV1Personalized Medicine (PM)R MedicineSupplementary DataRJournal article10.3389/fimmu.2024.136189115