Russell, Amy M.Shepherd, VictoriaWoolfall, KerryYoung, BridgetGillies, KatieVolkmer, AnnaJayes, MarkHuxtable, RichardPerkins, AlexanderNoor, Nurulamin M.Nickolls, BeverleyWade, Julia2023-03-012023-03-012023-02-28Russell, A M, Shepherd, V, Woolfall, K, Young, B, Gillies, K, Volkmer, A, Jayes, M, Huxtable, R, Perkins, A, Noor, N M, Nickolls, B & Wade, J 2023, 'Complex and alternate consent pathways in clinical trials : methodological and ethical challenges encountered by underserved groups and a call to action', Trials, vol. 24, no. 1, 151. https://doi.org/10.1186/s13063-023-07159-61745-6215RIS: urn:17F657FC47D41611DCEA77C704D19D2ARIS: Russell2023ORCID: /0000-0001-7890-2854/work/129952191https://hdl.handle.net/2164/20203Acknowledgements We would like to thank the wider contributors to the Complex and Alternate Consent Pathways group and the MRC-NIHR Trials Methodology Research Partnership who have participated in the discussions at various stages of this work. JW would like to acknowledge the support of the QuinteT research group, University of Bristol. Funding No funding was received for this work. VS is supported by a National Institute of Health Research Advanced Fellowship (CONSULT) funded by the Welsh government through Health and Care Research Wales (NIHR-FS(A)-2021). AMR is supported by a Wellcome Trust Fellowship (Capacity, Consent and Autonomy https://capacityconsent.leeds.ac.uk/) (219754/Z/19/Z). AV is supported by a National Institute for Health Research Advanced Fellowship (NIHR302240). KG is supported by funding from the Chief Scientist Office of the Scottish Government’s Health and Social Care Directorate (CZU/3/3). This work was supported by the MRC-NIHR Trials Methodology Research Partnership (MR/S014357/1). RH is supported in part by the Wellcome Trust (209841/Z/17/Z and 223290/Z/21/Z), EPSRC (EP/T020792/1), and the NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol. RH also serves on various local, regional, and national ethics committees and related groups. None of the organisations played a role in the drafting of this article, and the opinions stated are those of the authors.121017826engInformed consentClinical TrialsEthicsUndeserved populationsR MedicineWellcome Trust219754/Z/19/Z209841/Z/17/Z223290/Z/21/ZNational Institute for Health Research (NIHR)NIHR-FS(A)-2021NIHR302240Medical Research Council (MRC)MR/S014357/1Engineering and Physical Sciences Research Council (EPSRC)EP/T020792/1RJournal article10.1186/s13063-023-07159-6241