Lockhart, Deborah E. A.Stanley, MathewRaimi, Olawale G.Robinson, David A.Boldovjakova, DominikaSquair, Daniel R.Ferenbach, Andrew T.Fang, Wenxiavan Aalten, Daan M. F.2020-08-042020-08-042020-06-26Lockhart, D E A, Stanley, M, Raimi, O G, Robinson, D A, Boldovjakova, D, Squair, D R, Ferenbach, A T, Fang, W & van Aalten, D M F 2020, 'Targeting a critical step in fungal hexosamine biosynthesis', Journal of Biological Chemistry, vol. 295, no. 26, pp. 8678-8691. https://doi.org/10.1074/jbc.RA120.0129850021-9258ORCID: /0000-0002-4262-3842/work/76974405https://hdl.handle.net/2164/14861Acknowledgements We wish to thank the Dundee Drug Discovery Unit for access to the Fragment library and the European Synchrotron Radiation Facility, Grenoble and Diamond Light Source, Oxford for time at the beamline. The assistance from Mr Martin Kierans, School of Life Sciences, University of Dundee with the Electron Microscopy is gratefully acknowledged. Funding and additional information This work was supported by a Wellcome Trust Postdoctoral Research Training Fellowship for Clinicians (WT105772/A/14/Z) to DL and an MRC Programme Grant (MR/M004139/1) to DMFvA. DB was funded by a University of Aberdeen Summer Research Scholarship.1412776071516038engSDG 3 - Good Health and Well-beingfungiAspergillus fumigatuscell wallglucosamine 6-phosphate N-acetyltransferase (Gna1)resistancefragmentprotein-protein interactionvirulence factorchitinantifungal drug developmentX-ray crystallographyASPERGILLUS-FUMIGATUSPRACTICE GUIDELINESNIKKOMYCIN-ZSTRESS-RESPONSESTRUCTURAL VALIDATIONMURINE MODELCELL-WALLGALLERIA-MELLONELLA LARVAEINHIBITORSINFECTIOUS-DISEASES SOCIETYQ Science (General)Molecular BiologyBiochemistryCell BiologyMedical Research Council (MRC)MR/M004139/1Wellcome TrustWT105772/A/14/ZQ1Journal article10.1074/jbc.RA120.012985http://www.scopus.com/inward/record.url?scp=85087253752&partnerID=8YFLogxK29526